| Manhuaçu River | |
| River System: | Doce River |
| Mouth Location: | Minas Gerais, Brazil |
| Mouth Coordinates: | -19.4857°N -41.0888°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Manhuaçu River is a river of Minas Gerais state in southeastern Brazil.
The river is in the Doce River basin.It runs past the Feliciano Miguel Abdala Private Natural Heritage Reserve, located on its left bank, home to one of the last wild populations of northern muriqui woolly spider monkeys.