Mangostin Explained

Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure.

Source

The rind of partially ripe mangosteen fruit yields mangostin and also the related compound β-mangostin. Researchers conducted the optimization steps in order to increase the yield of α-mangostin extraction from the pericarp of the mangosteen and was able to achieve 9.2 g/kg DW.[1] The rind of fully ripe fruits also contains the xanthonoids gartanin, 8-disoxygartanin, and normangostin.

Research

Mangostin and a variety of other xanthonoids from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities.[2]

In animal studies, mangostin has been found to be a central nervous system depressant which causes sedation, decreased motor activity, and ptosis.[3]

Related compounds

A derivative of mangostin, mangostin-3,6-di-O-glucoside, is a central nervous system depressant and causes a rise in blood pressure.

Notes and References

  1. 1. 10.36877/pddbs.a0000072. A Rapid Method for the Retrieval of Bioactive Xanthone from Garcinia Mangostana: A Case Study of α-Mangostin. 2020. Khaw. Kooi Yeong. Ong. Yong Sze. Goh. Bey-Hing. Progress in Drug Discovery & Biomedical Science. 3. free.
  2. Jung H, Su B, Keller W, Mehta R, Kinghorn A . Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen) . J. Agric. Food Chem. . 54 . 6 . 2077–82 . 2006 . 16536578 . 10.1021/jf052649z.
  3. Arch Int Pharmacodyn Ther. . 1979 . 239 . 2 . 257–269 . Pharmacological profile of mangostin and its derivatives . Shankaranarayan D, Gopalakrishnan C, Kameswaran L . 314790.