Manesus (also spelled Manesos;) was a Parthian prince, who served as military governor and official (strategos and bidaxsh) of Parthian-ruled Mesopotamia and Parapotamia, in addition to being the ruler of the Arabs (arabarch) who lived in those areas. He was also collector of customs (παρ[αλή](πτου); perhaps a derivation of Iranian păhrbed).[1] He held these posts during the reign of King Vologases III (110–147).
Manesus was the son of the Parthian King Phraates and was active in the aftermath of Trajan's Parthian campaign.[2] He is attested in a Greek parchment from Dura-Europos (in modern-day Syria), dated to 120/1 AD (Μανήσου τοῦ Φραάτου τῶν Βατησα καὶ τ[ῶν] / [ἐλεύθε]ρων παρ[αλή](πτου) καὶ στρατηγοῦ Μεσοποταμίας καὶ Παραποταμίας καὶ ἀραβάρχου).[1]