| Mandy Debono | |
| Birth Date: | 1987 11, df=yes[1] |
| Position: | Defender |
| Currentclub: | Swieqi United |
| Years1: | 2002–2019 |
| Clubs1: | Hibernians |
| Years2: | 2019– |
| Clubs2: | Swieqi United |
| Caps2: | 2 |
| Goals2: | 0 |
| Nationalyears1: | 2006–2015 |
| Nationalteam1: | Malta |
| Nationalcaps1: | 33 |
| Nationalgoals1: | 0 |
| Ntupdate: | 9 April 2015 |
Mandy Debono (born 24 November 1987) is a Maltese footballer who plays as a defender for First Division club Swieqi United FC. She has been a member of the Malta women's national team.