| Mandres-en-Barrois | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Mandres-en-Barrois 55.svg |
| Arrondissement: | Bar-le-Duc |
| Canton: | Ligny-en-Barrois |
| Insee: | 55315 |
| Postal Code: | 55290 |
| Mayor: | Julien Robert[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | CC Portes de Meuse |
| Coordinates: | 48.4925°N 5.3908°W |
| Elevation M: | 367 |
| Elevation Min M: | 318 |
| Elevation Max M: | 400 |
| Area Km2: | 17.71 |
Mandres-en-Barrois (pronounced as /fr/) is a commune in the Meuse department in Grand Est in north-eastern France.