| Mandiana Prefecture | |
| Settlement Type: | Prefecture |
| Mapsize: | 300px |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Guinea |
| Subdivision Type: | Country |
| Subdivision Name: |  Guinea |
| Subdivision Type1: | Region |
| Subdivision Name1: | Kankan Region |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Mandiana |
| Area Total Km2: | 12825 |
| Population As Of: | 2014 census |
| Population Total: | 335999 |
| Population Density Km2: | auto |
| Population Blank1 Title: | Ethnicities |
| Timezone: | Guinea Standard Time |
| Utc Offset: | +0 |
Mandiana is a prefecture located in the Kankan Region of Guinea. The capital is Mandiana. The prefecture covers an area of 12,825 km.² and has a population of 335,999.
The prefecture is divided administratively into 12 sub-prefectures: