| Mamprusi District | |
| Settlement Type: | Former District Council |
| Pushpin Map: | Ghana |
| Pushpin Map Caption: | Location of Mamprusi District within Northern |
| Subdivision Type: | Country |
| Subdivision Name: |  Ghana |
| Subdivision Type1: | Region |
| Subdivision Name1: | Northern |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Gambaga |
| Leader Title: | District Executive |
| Timezone: | GMT |
| Utc Offset: | +0 |
| Coordinates: | 10.5306°N -0.4422°W |
| Iso Code: | GH-NP-__ |
Mamprusi District is a former district council that was located in North East Region, Ghana.
It was created as an ordinary district assembly in the Northern Region in 1975. However on 1988, it was split off into two new district assemblies: East Mamprusi District and West Mamprusi District. The district assembly was located in the northeast part of Northern Region and had Gambaga as its capital town.