| Mamou Prefecture | |
| Settlement Type: | Prefecture |
| Mapsize: | 300px |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Guinea |
| Subdivision Type: | Country |
| Subdivision Name: |  Guinea |
| Subdivision Type1: | Region |
| Subdivision Name1: | Mamou Region |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Mamou |
| Unit Pref: | Imperial |
| Area Total Km2: | 8000 |
| Population Total: | 222000 |
| Population Blank1 Title: | Ethnicities |
| Timezone: | Guinea Standard Time |
| Utc Offset: | +0 |
Mamou (Pular:) is a prefecture located in the Mamou Region of Guinea. The capital is Mamou. The prefecture covers an area of 8,000 km.² and has an estimated population of 222,000.
The prefecture is divided administratively into 14 sub-prefectures: