Mammaglobin-B Explained

Mammaglobin-B also known as secretoglobin family 2A member 1 is a protein that in humans is encoded by the SCGB2A1 gene.^{[1] [2]}

SCGB2A1 and breast cancer

SCGB2A1 expression is highly specific of mammary tissue, and has been used for identification and detection of disseminated breast cancer cells.^[3]

Further reading

• Molloy MP, Bolis S, Herbert BR, etal . Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value. . Electrophoresis . 18 . 15 . 2811–5 . 1998 . 9504814 . 10.1002/elps.1150181516 . 39202047 .
• Lehrer RI, Xu G, Abduragimov A, etal . Lipophilin, a novel heterodimeric protein of human tears. . FEBS Lett. . 432 . 3 . 163–7 . 1998 . 9720917 . 10.1016/S0014-5793(98)00852-7 . 205880914 . free . 1998FEBSL.432..163L .
• Zhao C, Nguyen T, Yusifov T, etal . Lipophilins: human peptides homologous to rat prostatein. . Biochem. Biophys. Res. Commun. . 256 . 1 . 147–55 . 1999 . 10066439 . 10.1006/bbrc.1999.0274 .
• Evans V, Vockler C, Friedlander M, etal . Lacryglobin in human tears, a potential marker for cancer. . Clin. Experiment. Ophthalmol. . 29 . 3 . 161–3 . 2001 . 11446459 . 10.1046/j.1442-9071.2001.00408.x . 41723656 .
• Carter D, Douglass JF, Cornellison CD, etal . Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer. . Biochemistry . 41 . 21 . 6714–22 . 2002 . 12022875 . 10.1021/bi0159884 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Izmailova E, Bertley FM, Huang Q, etal . HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. . Nat. Med. . 9 . 2 . 191–7 . 2003 . 12539042 . 10.1038/nm822 . 26145639 .
• Sjödin A, Guo D, Sørhaug S, etal . Dysregulated secretoglobin expression in human lung cancers. . Lung Cancer . 41 . 1 . 49–56 . 2003 . 12826312 . 10.1016/S0169-5002(03)00126-0 .
• Ouellette RJ, Richard D, Maïcas E . RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes. . Am. J. Clin. Pathol. . 121 . 5 . 637–43 . 2004 . 15151203 . 10.1309/MMAC-TXT5-5L8Q-TKC1 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Xiao F, Mirwald A, Papaioannou M, etal . Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors. . Mol. Endocrinol. . 19 . 12 . 2964–78 . 2006 . 16020486 . 10.1210/me.2004-0408 . free .
• Bernstein JL, Godbold JH, Raptis G, etal . Identification of mammaglobin as a novel serum marker for breast cancer. . Clin. Cancer Res. . 11 . 18 . 6528–35 . 2005 . 16166429 . 10.1158/1078-0432.CCR-05-0415 . free .

Notes and References

1. Becker RM, Darrow C, Zimonjic DB, Popescu NC, Watson MA, Fleming TP . Identification of mammaglobin B, a novel member of the uteroglobin gene family . Genomics . 54 . 1 . 70–8 . Jan 1999 . 9806831 . 10.1006/geno.1998.5539 .
2. Web site: Entrez Gene: SCGB2A1 secretoglobin, family 2A, member 1.
3. M . Lacroix . Significance, detection and markers of disseminated breast cancer cells . . . 2006 . 13 . 1033–1067. 17158753. 10.1677/ERC-06-0001 . 4 . Marc Lacroix (biochemist). free .