Malonyl-S-ACP:biotin-protein carboxyltransferase explained

Malonyl-S-ACP:biotin-protein carboxyltransferase
Ec Number:	2.1.3.10

Malonyl-S-ACP:biotin-protein carboxyltransferase (malonyl-S-acyl-carrier protein:biotin-protein carboxyltransferase, MadC/MadD, MadC,D, malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxyltransferase) is an enzyme with systematic name malonyl-(acyl-carrier protein):biotinyl-(protein) carboxytransferase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

malonyl-[acyl-carrier protein] + biotinyl-[protein]

\rightleftharpoons acetyl-[acyl-carrier protein] + carboxybiotinyl-[protein]

This enzyme is a component of EC 4.1.1.89, biotin-dependent malonate decarboxylase.

Notes and References

1. Berg M, Hilbi H, Dimroth P . Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function . European Journal of Biochemistry . 245 . 1 . 103–15 . April 1997 . 9128730 . 10.1111/j.1432-1033.1997.00103.x . free .
2. Stereochemical course of malonate decarboxylase in Malonomonas rubra has biotin decarboxylation with retention . Micklefield J, Harris KJ, Gröger S, Mocek U, Hilbi H, Dimroth P, Floss HG . J. Am. Chem. Soc. . 1995 . 117 . 1153–1154 . 10.1021/ja00108a042.
3. Dimroth P, Hilbi H . Enzymic and genetic basis for bacterial growth on malonate . Molecular Microbiology . 25 . 1 . 3–10 . July 1997 . 11902724 . 10.1046/j.1365-2958.1997.4611824.x . free .