Malonate decarboxylase holo-(acyl-carrier protein) synthase explained

Malonate decarboxylase holo-(acyl-carrier protein) synthase
Ec Number:	2.7.7.66

Malonate decarboxylase holo-(acyl-carrier protein) synthase (holo ACP synthase, '2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo ACP 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA transferase, MdcG, 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-malonate-decarboxylase adenylyltransferase, holo-malonate-decarboxylase synthase) is an enzyme with systematic name 2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-malonate-decarboxylase 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

2'-(5-triphosphoribosyl)-3'-dephospho-CoA + malonate decarboxylase apo-[acyl-carrier protein]

\rightleftharpoons malonate decarboxylase holo-[acyl-carrier protein] + diphosphate

The delta subunit of malonate decarboxylase serves as an acyl-carrier protein (ACP) .

Notes and References

1. Hoenke S, Wild MR, Dimroth P . Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase . Biochemistry . 39 . 43 . 13223–32 . October 2000 . 11052675 . 10.1021/bi0011532 .
2. Hoenke S, Schmid M, Dimroth P . Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases . Biochemistry . 39 . 43 . 13233–40 . October 2000 . 11052676 . 10.1021/bi001154u .