Malcolm Rowland Explained

Malcolm Rowland
Birth Place:London, UK
Nationality:English
Known For:Pharmacy

Malcolm Rowland FBPhS[1] (born 5 August 1939, in London) is Emeritus Professor of Pharmacy, University of Manchester,[2] and adjunct professor, University of California San Francisco. His research in pharmacology, has been particularly in physiologically based pharmacokinetics (that deals with the movement in time of drugs and their metabolites within the body).[3] He has written several textbooks on the subject.

He studied Pharmacy at Chelsea College (now Kings College), an internal college of the University of London, gaining a B.Pharm (1961) and subsequently a Ph.D (1965).

Academic career

Following his Ph.D. degree research into the pharmacokinetics of amphetamines,[4] he took up a postdoctoral research appointment in the laboratory of Sidney Riegelman, School of Pharmacy, University of California, San Francisco (1965-1967), studying the pharmacokinetics of aspirin, and then took up a faculty position there (1967–75). While at UCSF.[5] Rowland became a member of the joint Pharmacy-Medicine NIGMS funded program in Clinical Pharmacology, and moved his research from a prevailing descriptive approach to a more mechanistic, physiologically-based one,[6] including the clearance concept[7] [8] that helped lay the foundations of modern pharmacokinetics. Together with Riegelman and Leslie Benet he founded the Journal of Pharmacokinetics and Biopharmaceutics (1973)[9] (renamed Journal of Pharmacokinetics and Pharmacodynamics, 2001), and was a senior editor of it until 2007.

In 1975 Rowland returned to the United Kingdom to take up a position of Professor of Pharmacy, University of Manchester where he extended his research on physiologically based pharmacokinetics[10] [11] including development of an in silico method for predicting tissue distribution of drugs based on tissue composition and physicochemical properties.[12] In 1983 he founded Medeval,[13] undertaking early stage clinical evaluation of new medicines under development. Together with Brian Houston and Leon Aarons he established the Centre for Applied Pharmacokinetic Research (1996).[14] He has promoted the application of microdosing in clinical drug development.[15] [16]

He headed the School of Pharmacy at Manchester on two occasions, 1988-1991 and 1998-2001, periods involving the move to clinical pharmacy and moving Pharmacy from the Faculty of Science and Engineering to the Faculty of Medicine, in recognition of the changing professional role of pharmacists from fabricator to health care advisor on medicines. Rowland has trained 90 Ph.D. students and scientists from a variety of disciplines. He also established ongoing annual postgraduate workshops in basic pharmacokinetics with Tomas Tozer (1977), and in advanced methods in pharmacokinetics and pharmacodynamics with Lewis Sheiner (1981).[17]

Rowland was president of EUFEPS (European Federation for Pharmaceutical Sciences, 1996-1999),[18] and a Vice-President of FIP (International Pharmaceutical Federation,2001-2009).[19]

Published works

Rowland has published over 270 research articles in international peer-reviewed journals, and over 60 book chapters and conference reports. He co-authored with Thomas Tozer two standard textbooks: Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications, now in its 5th edition, and Essentials of Pharmacokinetics and Pharmacodynamics.[20]

Honours and awards

He received honorary degrees from University of Poitiers, France (D.Sc.1981), Uppsala University, Sweden (FarmDhc, 1989),[21] and Athens University, Greece (D.Sc., 2011).[22] He was made Fellow, Academy of Medical Sciences (2001), Fellow, British Pharmacological Society (2012), and Honorary Fellow, American College of Clinical Pharmacology (2003).[23] He received the Scheele Award (Swedish Academy of Pharmaceutical Sciences, 1984),[24] the Distinguished Investigator Award (American College of Clinical Pharmacology, 2007), the New Safe Medicines Faster Award (EUFEPS, 2009), Research Achievement Award in Pharmacokinetics (American Association of Pharmaceutical Scientists, 1994),[25] the Sheiner-Beal Award in Pharmacometrics (American Society of Clinical Pharmacology and Therapeutics, 2012)[26] and the Ariens Award (Dutch Pharmacological Society, 2020)[27] ., as well as the Harrison Memorial Medal (Royal Pharmaceutical Society of Great Britain, 1992)[28] and Host Madsen Medal (International Pharmaceutical Federation, 2011).[29]

Personal life

Malcolm married Dawn Shane, in 1965. They have two daughters, and 5 grandchildren.

Notes and References

  1. https://www.bps.ac.uk/about/who-we-are/fellows-directory/professor-malcolm-rowland/f9fc56b2-d7f6-e311-88a7-001dd8b721a7 Fellows
  2. Web site: Search for people | The University of Manchester. personalpages.manchester.ac.uk.
  3. Web site: Distinguished Pharmaceutical Scientist: Malcolm Rowland (2006). YouTube.
  4. Rowland . M . Chemical and biochemical studies with amphetamine . 1965 . 1006126238 .
  5. Web site: 1967–1978: The Riegelman Chairship · History of the Department of Bioengineering and Therapeutic Sciences.
  6. Benowitz . Neal . Forsyth . Ralph P. . Melmon . Kenneth L. . Rowland . Malcolm . Lidocaine disposition kinetics in monkey and man; I. Prediction by a perfusion model . Clinical Pharmacology & Therapeutics . July 1974 . 16 . 1part1 . 87–98 . 10.1002/cpt1974161part187 . 4210516 . 32330285 .
  7. Rowland . Malcolm . Benet . Leslie Z. . Graham . Garry G. . Clearance concepts in pharmacokinetics . Journal of Pharmacokinetics and Biopharmaceutics . April 1973 . 1 . 2 . 123–136 . 10.1007/BF01059626 . 4764426 . 9361701 .
  8. Pang . K. Sandy . Rowland . Malcolm . Hepatic clearance of drugs. I. Theoretical considerations of a 'well-stirred' model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance . Journal of Pharmacokinetics and Biopharmaceutics . December 1977 . 5 . 6 . 625–653 . 10.1007/BF01059688 . 599411 . 28316323 .
  9. Bonate . Peter L. . On the shoulders of giants… . Journal of Pharmacokinetics and Pharmacodynamics . February 2020 . 47 . 1 . 1. 10.1007/s10928-020-09674-4 . 31960232 . 210717345 . free .
  10. Roberts . Michael S. . Rowland . Malcolm . A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations . Journal of Pharmacokinetics and Biopharmaceutics . 1 June 1986 . 14 . 3 . 227–260 . 10.1007/BF01106706 . 3783446 . 44671643 .
  11. Cheung . S Y A . Rodgers . T . Aarons . L . Gueorguieva . I . Dickinson . G L . Murby . S . Brown . C . Collins . B . Rowland . M . Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose: WBPBPK modelling of β-blockers in the rat . British Journal of Pharmacology . January 2018 . 175 . 1 . 67–83 . 10.1111/bph.14071 . 29053169 . 5740248 .
  12. Rodgers . Trudy . Rowland . Malcolm . Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions . Journal of Pharmaceutical Sciences . June 2006 . 95 . 6 . 1238–1257 . 10.1002/jps.20502 . 16639716 .
  13. Web site: Drug development | the University of Manchester.
  14. Web site: Home . capkr.manchester.ac.uk.
  15. Lappin . Graham . Shishikura . Yoko . Jochemsen . Roeline . Weaver . Richard John . Gesson . Charlotte . Brian Houston . J. . Oosterhuis . Berend . Bjerrum . Ole J. . Grynkiewicz . Grzegorz . Alder . Jane . Rowland . Malcolm . Garner . Colin . Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers . European Journal of Pharmaceutical Sciences . June 2011 . 43 . 3 . 141–150 . 10.1016/j.ejps.2011.04.009 . 21540108 .
  16. Burt . Tal . Young . Graeme . Lee . Wooin . Kusuhara . Hiroyuki . Langer . Oliver . Rowland . Malcolm . Sugiyama . Yuichi . Phase 0/microdosing approaches: time for mainstream application in drug development? . Nature Reviews Drug Discovery . November 2020 . 19 . 11 . 801–818 . 10.1038/s41573-020-0080-x . 32901140 . 221573443 . free .
  17. Web site: Home . pkworkshops.com.
  18. Web site: History - Eufeps .
  19. Web site: Structure and statutes. www.fip.org.
  20. Web site: Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications, 5e. January 2020. Derendorf. Hartmut.
  21. Web site: Honorary Doctors of the Faculty of Pharmacy - Uppsala University, Sweden.
  22. Web site: ΕΚΠΑ: Τμήμα Φαρμακευτικής - Επίτιμοι Διδάκτορες.
  23. Web site: Prior Recognition Award Winners | ACCP.
  24. Web site: Former Laurates.
  25. Web site: Past Award Recipients – AAPS Historical Awards. AAPS. 24 September 2023.
  26. Web site: Sheiner-Beal Pharmacometrics Award. ascpt.org . https://web.archive.org/web/20210603005902/https://www.ascpt.org/Portals/28/docs/Awards/Criteria%20and%20Past%20Recipients/2021%20Awards/Award%20Criteria%20and%20Past%20Recipients%202021%20Sheiner-Beal.pdf?ver=2021-05-03-114840-033 . 3 June 2021.
  27. Web site: Ariens Award – NVF.
  28. Web site: Hanbury and Harrison Medal winners announced | Royal Pharmaceutical Society | RPS.
  29. Web site: Awards. fip.org.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Malcolm Rowland".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.