| Malate—CoA ligase | |
| Ec Number: | 6.2.1.9 |
| Cas Number: | 37318-58-4 |
| Go Code: | 0050074 |
In enzymology, a malate—CoA ligase is an enzyme that catalyzes the chemical reaction
ATP + malate + CoA
\rightleftharpoons
The 3 substrates of this enzyme are ATP, malate, and CoA, whereas its 3 products are ADP, phosphate, and malyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is malate:CoA ligase (ADP-forming). Other names in common use include malyl-CoA synthetase, malyl coenzyme A synthetase, and malate thiokinase. This enzyme participates in glyoxylate and dicarboxylate metabolism.