| Official Name: | Makokou |
| Pushpin Map: | Gabon |
| Pushpin Label Position: | bottom |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Gabon |
| Subdivision Type: | Country |
| Subdivision Name: |  Gabon |
| Subdivision Name1: | Ogooué-Ivindo Province |
| Subdivision Type2: | Department |
| Subdivision Name2: | Ivindo |
| Leader Title: | Mayor |
| Leader Name: | Andre Nkoghe Ella |
| Unit Pref: | Imperial |
| Population As Of: | 2006 |
| Population Total: | 13881 |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Coordinates: | 0.5667°N 64°W |
| Elevation M: | 308 |
Makokou is the regional capital of the Ogooué-Ivindo province in Gabon. Its coordinates are 0.5667°N 64°W. Its altitude is 308 m. Its population in 2004 is around 16,600.
The city lies on the Ivindo River and the N4 road. It grew around iron ore mining and lies near the Ivindo National Park.
A branch of the Trans-Gabon Railway was originally planned to terminate in the town, but the route was abandoned for what are often described as political reasons. At the time, the price of iron ore from the nearby iron ore mines was depressed. In 2006, proposals to build this branch with a possible extension to other iron ore mines at Mbala, Cameroon are being considered. At new deep water port at Santa Clara would be part of the project.
The town has one airport, Makokou Airport.
Its Cathédrale Notre-Dame des Victoires is the see of the Apostolic Vicariate of Makokou, the country's last Roman Catholic missionary circonscription.
Former Gabonese Prime Ministers Emmanuel Issoze-Ngondet and Alain Claude Bilie By Nze were born in this city.
Makokou has a tropical dry savanna climate (Köppen climate classification As).