| Maki Esther Ortiz Domínguez | |
| Office: | Mayoress of Reynosa |
| Term Start: | 1 October 2016 |
| Term End: | 30 September 2021 |
| Predecessor: | Jose Elias Leal |
| Successor: | Carlos Víctor Peña Ortiz |
| Office2: | Senator of the Senate of the Republic from Tamaulipas |
| Term Start2: | 1 September 2012 |
| Term End2: | 4 February 2016 |
| Predecessor2: | Nelly Gonzalez Aguilar |
| Successor2: | Andrea Garcia Garcia |
| Birth Date: | 23 September 1962 |
| Birth Place: | Reynosa, Tamaulipas, Mexico |
| Party: | (until 2021) |
| Spouse: | Carlos Peña Garza |
| Children: | Carlos Victor Peña Ortiz |
| Profession: | doctor and politician |
Maki Esther Ortiz Domínguez (born 23 September 1962) is a Mexican politician formerly affiliated with the Ecologist Green Party of Mexico. She served as mayor of Reynosa from 2016 to 2021, the first woman in the history of the city elected to the position. She also became the first mayoress to be re-elected for a consecutive second term. She served as a senator for Tamaulipas in the 62nd Congress (2012 to 2015). She also served as a federal deputy during the 59th Congress (2003 to 2006).[1]
Ortiz Domínguez is seeking election as one of Tamaulipas's senators in the 2024 Senate election, occupying the second place on the Ecologist Green Party of Mexico's two-name formula.[2]