| State: | ME |
| Type: | ME |
| Route: | 22 |
| Map Custom: | yes |
| Length Mi: | 19.48 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Direction A: | West |
| Terminus A: | in Buxton |
| Direction B: | East |
| Junction: | |
| Terminus B: | in Portland |
| Counties: | York, Cumberland |
| Established: | 1939, 1958 (current alignment) |
| Previous Type: | ME |
| Previous Route: | 18 |
| Next Type: | ME |
| Next Route: | 23 |
State Route 22 (SR 22) is a 19.4miles state highway located in southwestern Maine. It serves the western suburbs of Portland, running from SR 35 in Buxton east into the city, where it ends at SR 77.