| State: | ME |
| Type: | ME |
| Route: | 181 |
| Map Custom: | yes |
| Length Mi: | 12.45 |
| Length Ref: | [1] |
| Alternate Name: | Mariaville Road |
| Direction A: | South |
| Terminus A: | in Otis |
| Direction B: | North |
| Terminus B: | in Amherst |
| Counties: | Hancock |
| Previous Type: | SR |
| Previous Route: | 180 |
| Next Type: | SR |
| Next Route: | 182 |
State Route 181 (SR 181) is a 12.45miles route in the US state of Maine from SR 180 near Mariaville to SR 9 in Amherst. It serves as the main through route through Mariaville.