| Noor Muhammad Khan Kalhoro نور محمد خان ڪلهوڙو | |
| Khuda Yar Khan Mian | |
| Succession: | 1st Nawab of Sindh |
| Reign: | 1737–1755 |
| Predecessor: | Position established |
| Successor: | Muhammad Muradyab Khan |
| Birth Date: | 6 August 1698 |
| Death Place: | Jaisalmer, Jaisalmer State |
| Issue: | Mian Muradyab, Mian Ghulam Shah,Mian Athar |
| Full Name: | Mian Noor Muhammad Khan Kalhoro |
| House: | Kalhora dynasty |
| Father: | Yar Muhammad Kalhoro |
| Religion: | Sunni Islam |
Mian Noor Muhammad Khan Kalhoro (1698 – 1755) (Sindhi: مياں نور محمد خان ڪلهوڙو) ruled over Sindh as Subahdar of the Mughal Emperor from 1719 till 1737. He then consolidated his power over the entire of Sindh, subjugating Bakhar Sarkar (Northern Sindh), Sehwan Sarkar (Central Sindh), and Thatta Sarkar (Southern Sindh), and thus established a sovereign state, independent of Mughal suzerainty.
In 1737, Kalhoro assumed the title of Kalhora Nawab of Sindh and was given the title Nawab Khuda-Yar Khan by the Mughal Emperor Muhammad Shah.[1] In 1739, during Nader Shah's invasion of India, Mian fled to Umerkot for shelter but was captured by the King of Iran. Mian Noor Mohammad Kalhoro sent a small force to assassinate Nader Shah and turn events in favor of the Mughal Emperor during the Battle of Karnal in 1739, but this plot failed.