| Madonna with Child and Saints | |
| Artist: | Luca Signorelli |
| Year: | c. 1519–1523 |
| Medium: | Tempera on panel |
| Height Metric: | 357 |
| Width Metric: | 248 |
| Metric Unit: | cm |
| Imperial Unit: | in |
| City: | Arezzo |
The Madonna with Child and Saints is a painting by the Italian late Renaissance painter Luca Signorelli, executed around 1519-1523. It is housed in the, in Arezzo. The picture is a traditional Holy Conversation composition.
The painting was commissioned by the Brotherhood of St. Jerome in Arezzo for their seat. The work was executed in Cortona and was brought to Arezzo by the painter himself, who was then in his seventies (here, he resided in the Vasari family's house and met the young Giorgio Vasari, his future biographer, who started to practice painting after Signorelli's suggestion).
It is the last work by Signorelli, who died after returning to Cortona.