| Weirton Madonna High School | |
| Streetaddress: | 150 Michael Way |
| City: | Weirton |
| State: | West Virginia |
| County: | (Hancock County) |
| Zipcode: | 26062-3753 |
| Country: | United States of America |
| Coordinates: | 40.4097°N -80.5514°W |
| Religion: | Roman Catholic |
| Principal: | Philip Rujak |
| Type: | Private, Coeducational |
| Tuition: | $4,500 (Catholic), $5,500 (non-Catholic) |
| Grades: | 7–12 |
| Accreditation: | North Central Association of Colleges and Schools[1] |
| Nickname: | Blue Dons |
| Publication: | The Little Magazine (Literary Magazine) |
| Established: | 1955 |
| Enrollment: | 185 |
| Free Label: | Designated Pastor |
| Free Text: | Very Rev. Fr. Dennis Schuelkens |
| Free Label1: | Dean of Students |
| Free Text1: | Darrin Hicks |
| Homepage: | http://www.weirtonmadonna.org |
Weirton Madonna High School is a private, Roman Catholic high school in Weirton, West Virginia. It is part of the Roman Catholic Diocese of Wheeling-Charleston.
As of the 2017-18 school year, the total student enrollment was 171. The ethnic makeup of the school was 97.1% White, .6% Asian and 2.3% Multiracial.[2]