| Madingo-Kayes | |
| Settlement Type: | District |
| Mapsize: | 350px |
| Subdivision Type: | Country |
| Subdivision Name: | Republic of the Congo |
| Subdivision Type1: | Region |
| Subdivision Name1: | Kouilou Region |
| Unit Pref: | Imperial |
| Area Total Km2: | 2,886 |
| Population As Of: | 2023 census |
| Population Footnotes: | [1] |
| Population Total: | 8,574 |
| Population Density Km2: | auto |
| Timezone: | GMT +1 |
| Utc Offset: | +1 |
Madingo-Kayes is a district in the Kouilou Region of far south-western Republic of the Congo. The capital lies at Madingo-Kayes.
The area is known for its archaeological site Madingo Kayes.