| Official Name: | Macultepec |
| Subdivision Type: | Country |
| Subdivision Name: | Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Tabasco |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | Centro |
| Leader Title: | Municipal delegate |
| Leader Name: | Benito Ortiz (PRI) |
| Established Title: | Founded |
| Established Date: | 1744 |
| Population As Of: | 2005 census |
| Population Total: | 6 624 |
| Timezone: | Central Standard Time |
| Elevation M: | 10 |
| Postal Code: | 86250 |
Macultepec is a village of the Centro municipality, in the Mexican state of Tabasco. The etymology of Macultepec's name comes from the Chontal Macuiltepeque, meaning "on five hills".
It is one of seven villages of the Centro municipality and one of 13 Regional Development Centers (DCR) that develop the majority of the economic and social activities of the municipality.
Founded officially in 1744 by the Spaniard Ignacio Isidro de Avalos, employee of the Pardos Company.