| Official Name: | Macuelizo |
| Pushpin Map: | Honduras |
| Pushpin Label Position: | right |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Honduras |
| Subdivision Type: | Country |
| Subdivision Name: | Honduras |
| Subdivision Type1: | Department |
| Subdivision Name1: | Santa Bárbara |
| Subdivision Type2: | Villages |
| Subdivision Name2: | 38 |
| Area Total Km2: | 250.45 |
| Population As Of: | 2015 |
| Settlement Type: | Municipality |
| Population Total: | 35500 |
| Population Density Km2: | auto |
| Blank1 Name: | Climate |
| Blank1 Info: | Aw |
| Coordinates: | 15.3°N -120°W |
Macuelizo (pronounced as /es/) is a municipality in the Honduran department of Santa Bárbara. It's located a few kilometers north of the CA-4 highway, which connects San Pedro Sula to the Salvadoran border via Santa Rosa de Copán.
At the time of the 2013 Honduras census, Macuelizo municipality had a population of 34,401. Of these, 83.03% were Mestizo, 12.36% White, 2.26% Black or Afro-Honduran, 0.86% Indigenous and 1.49% others.[1]