| Macroregion One | |
| Native Name: | Macroregiunea Unu |
| Settlement Type: | Region |
| Subdivision Type: | Country |
| Subdivision Name: |  Romania |
| Area Total Km2: | 68,241 |
| Population Total: | 4,792,860 |
| Population As Of: | 2021 census |
| Population Density Km2: | auto |
| Timezone1: | EET |
| Utc Offset1: | +2 |
| Timezone1 Dst: | EEST |
| Utc Offset1 Dst: | +3 |
Macroregion One (Romanian: Macroregiunea Unu) is a statistical (NUTS 1) region of Romania. It consists of two development regions (Northwest[1] and Center), twelve counties, respectively.
Due to geographical position, climate expresses the natural setting of the relief, region benefiting from a temperate continental climate with warm summers, cold winters, high precipitation, with small differences between mountain, plain and hilly areas. In the village of Bod (Brașov County), was recorded the absolute minimum temperature (−38.5 °C), on January 25, 1942.[2]