CCL22 explained

C-C motif chemokine 22 is a protein that in humans is encoded by the CCL22 gene.^{[1] [2] [3]}

The protein encoded by this gene is secreted by dendritic cells and macrophages, and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4.^[4] The gene for CCL22 is located in human chromosome 16 in a cluster with other chemokines called CX3CL1 and CCL17.^{[5] [6]}

Further reading

• Robertson MJ . Role of chemokines in the biology of natural killer cells. . J. Leukoc. Biol. . 71 . 2 . 173–83 . 2002 . 10.1189/jlb.71.2.173 . 11818437 . 720060 .
• Gear AR, Camerini D . Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. . Microcirculation . 10 . 3–4 . 335–50 . 2003 . 12851650 . 10.1038/sj.mn.7800198 . 10791409 .
• Chang M, McNinch J, Elias C . Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes. . J. Biol. Chem. . 272 . 40 . 25229–37 . 1997 . 9312138 . 10.1074/jbc.272.40.25229 . etal. free .
• Pal R, Garzino-Demo A, Markham PD . Inhibition of HIV-1 infection by the beta-chemokine MDC. . Science . 278 . 5338 . 695–8 . 1997 . 9381181 . 10.1126/science.278.5338.695 . 1997Sci...278..695P . etal.
• Imai T, Chantry D, Raport CJ . Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. . J. Biol. Chem. . 273 . 3 . 1764–8 . 1998 . 9430724 . 10.1074/jbc.273.3.1764 . etal. free .
• Struyf S, Proost P, Sozzani S . Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor. . J. Immunol. . 161 . 6 . 2672–5 . 1998 . 10.4049/jimmunol.161.6.2672 . 9743322 . etal. free .
• Meucci O, Fatatis A, Simen AA . Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 24 . 14500–5 . 1998 . 9826729 . 10.1073/pnas.95.24.14500 . 24402 . 1998PNAS...9514500M . etal. free .
• Proost P, Struyf S, Schols D . Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction. . J. Biol. Chem. . 274 . 7 . 3988–93 . 1999 . 9933589 . 10.1074/jbc.274.7.3988 . etal. free .
• Loftus BJ, Kim UJ, Sneddon VP . Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. . Genomics . 60 . 3 . 295–308 . 1999 . 10493829 . 10.1006/geno.1999.5927 . etal.
• Annunziato F, Romagnani P, Cosmi L . Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection. . J. Immunol. . 165 . 1 . 238–46 . 2000 . 10861057 . 10.4049/jimmunol.165.1.238. etal. free .
• Vulcano M, Albanesi C, Stoppacciaro A . Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. . Eur. J. Immunol. . 31 . 3 . 812–22 . 2001 . 11241286 . 10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L . etal. free . 11379/240109 . free .
• Berin MC, Dwinell MB, Eckmann L, Kagnoff MF . Production of MDC/CCL22 by human intestinal epithelial cells. . Am. J. Physiol. Gastrointest. Liver Physiol. . 280 . 6 . G1217–26 . 2001 . 11352815 . 10.1152/ajpgi.2001.280.6.G1217. 6628796 .
• Lambeir AM, Proost P, Durinx C . Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family. . J. Biol. Chem. . 276 . 32 . 29839–45 . 2001 . 11390394 . 10.1074/jbc.M103106200 . etal. free .
• Wakahara S, Fujii Y, Nakao T . Gene expression profiles for Fc epsilon RI, cytokines and chemokines upon Fc epsilon RI activation in human cultured mast cells derived from peripheral blood. . Cytokine . 16 . 4 . 143–52 . 2002 . 11792124 . 10.1006/cyto.2001.0958 . etal.
• Ghia P, Strola G, Granziero L . Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. . Eur. J. Immunol. . 32 . 5 . 1403–13 . 2002 . 11981828 . 10.1002/1521-4141(200205)32:5<1403::AID-IMMU1403>3.0.CO;2-Y . etal. free .
• D'Ambrosio D, Albanesi C, Lang R . Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion. . J. Immunol. . 169 . 5 . 2303–12 . 2002 . 12193695 . 10.4049/jimmunol.169.5.2303. etal. free .
• Campbell JD, Stinson MJ, Simons FE, HayGlass KT . Systemic chemokine and chemokine receptor responses are divergent in allergic versus non-allergic humans. . Int. Immunol. . 14 . 11 . 1255–62 . 2003 . 12407016 . 10.1093/intimm/dxf098 . free .

Notes and References

1. Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW . Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells . J Exp Med . 185 . 9 . 1595–604 . Jun 1997 . 9151897 . 2196293 . 10.1084/jem.185.9.1595 .
2. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O . Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13 . Cytogenet Cell Genet . 81 . 1 . 10–1 . Oct 1998 . 9691168 . 10.1159/000015000 . 2024-07-29 . 46851784 .
3. Web site: Entrez Gene: CCL22 chemokine (C-C motif) ligand 22.
4. Vulcano M, Albanesi C, Stoppacciaro A, Bagnati R, D'Amico G, Struyf S, Transidico P, Bonecchi R, Del Prete A, Allavena P, Ruco LP, Chiabrando C, Girolomoni G, Mantovani A, Sozzani S . Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo . Eur. J. Immunol. . 31 . 3 . 812–22 . 2001 . 11241286 . 10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L . free . 11379/240109 . free .
5. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O . Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13 . Cytogenet. Cell Genet. . 81 . 1 . 10–1 . 1998 . 9691168 . 10.1159/000015000 . 2024-07-29 . 46851784 .
6. Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD . Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q . Genomics . 60 . 3 . 295–308 . 1999 . 10493829 . 10.1006/geno.1999.5927 .