Macelignan Explained

Macelignan (Anwulignan) is a lignan. It can be found in Myristica fragrans, the nutmeg.

Medical research

One study has shown that macelignan may exert antimicrobial and anticariogenic activity against Streptococcus mutans, but this is not a currently used treatment.[1] [2]

Macelignan may also act as an antidiabetic molecule via PPAR signaling[3] and upregulate adipocyte gene expression[4]

Macelignan may contain antioxidant and anti-inflammatory properties[5] and is marketed in breast enhancement creams for its anti-aging properties.[6]

Notes and References

  1. Dental Caries and Medicinal Plants –An Overview. B. Parimala Devi and R. Ramasubramaniaraj, Journal of Pharmacy Research 2009, 2(11),1669-1675 Web site: Dental Caries and Medicinal Plants –An Overview - B.Parimala Devi*, R.Ramasubramaniaraja - Journal of Pharmacy Research . 2011-08-27 . dead . https://web.archive.org/web/20110723075209/http://jpronline.info/article/view/906/708 . 2011-07-23 .
  2. Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. J.Y. Chung, J.H. Choo, M.H. Lee and J.K. Hwang, Phytomedicine, Volume 13, Issue 4, 13 March 2006, Pages 261-266,
  3. Therapeutic Potential of Peroxisome Proliferators–Activated Receptor-α/γ Dual Agonist With Alleviation of Endoplasmic Reticulum Stress for the Treatment of Diabetes http://diabetes.diabetesjournals.org/content/57/3/737.long
  4. Paul S, Hwang JK, Kim HY, Jeon WK, Chung C, Han JS . Multiple biological properties of macelignan and its pharmacological implications . . 36 . 3 . 264–72 . March 2013 . 23435944 . 10.1007/s12272-013-0048-z . 27489770 .
  5. Lee. Kyung-Eun. Mun. Sukyeong. Pyun. Hee-Bong. Kim. Myung-Suk. Hwang. Jae-Kwan. 2012. Effects of macelignan isolated from Myristica fragrans (Nutmeg) on expression of matrix metalloproteinase-1 and type I procollagen in UVB-irradiated human skin fibroblasts. Biological & Pharmaceutical Bulletin. 35. 10. 1669–1675. 10.1248/bpb.b12-00037. 1347-5215. 23037157. free.
  6. Web site: says. Tee O.. Best Breast Enlargement Creams Reviewed [UPDATED]]. 2020-08-07. BreastEnlargement.name. en-US.

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