| Competition: | Macedonian Second League |
| Season: | 2005–06 |
| Winners: | Pelister |
| Promoted: | Pelister Napredok |
| Relegated: | Novaci Mladost Sushica |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 Macedonian Second Football League was the fourteenth season since its establishment. It began on 6 August 2005 and ended on 20 May 2006.[1]
| Club | City | Stadium | Capacity | |
|---|---|---|---|---|
| Karaorman | Struga | Stadion Gradska Plazha | 500 | |
| Lozar | Demir Kapija | Gradski stadion Demir Kapija | 500 | |
| Madjari Solidarnost | Skopje | Stadion Boris Trajkovski | 3,000 | |
| Metalurg | Skopje | Stadion Zhelezarnica | 3,000 | |
| Mladost | Sushica | Stadion Sushica | 1,500 | |
| Napredok | Kichevo | Gradski stadion Kichevo | 5,000 | |
| Novaci 2005 | Novaci | Stadion Novaci | 500 | |
| Pelister | Bitola | Stadion Tumbe Kafe | 8,000 | |
| Skopje | Skopje | Stadion Avtokomanda | 4,000 | |
| Sloga Jugomagnat | Skopje | Chair Stadium | 6,000 | |
| Teteks | Tetovo | Gradski stadion Tetovo | 15,000 | |
| Turnovo | Turnovo | Stadion Kukush | 1,500 |
Every team will play three times against each other team for a total of 33 matches. The first 22 matchdays will consist of a regular double round-robin schedule. The league standings at this point will then be used to determine the games for the last 11 matchdays.
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