| Macchia d'Isernia | |
| Official Name: | Comune di Macchia d'Isernia |
| Coordinates: | 41.5667°N 24°W |
| Region: | Molise |
| Province: | Isernia (IS) |
| Mayor: | Giovanni Martino |
| Area Total Km2: | 17.71 |
| Population Footnotes: | [1] |
| Population Total: | 1008 |
| Population As Of: | 31 August 2022 |
| Population Demonym: | Macchiaroli |
| Elevation M: | 360 |
| Postal Code: | 86070 |
| Area Code: | 0865 |
Macchia d'Isernia is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about 40km (30miles) west of Campobasso and about 7km (04miles) southwest of Isernia.
Macchia d'Isernia borders the following municipalities: Colli a Volturno, Fornelli, Isernia, Monteroduni, Sant'Agapito.