| Macauã River | |
| Pushpin Map: | Brazil |
| River System: | Iaco River |
| Source1 Location: | Acre state |
| Mouth Location: | Iaco River, Sena Madureira, Acre |
| Mouth Coordinates: | -9.1876°N -68.7179°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
Macauã River is a river of Acre state in western Brazil, a tributary of the Iaco River.
The river forms most of the southeast boundary of the Macauã National Forest, a sustainable use conservation unit created in 1988.It flows through the northern part of the São Francisco National Forest, a sustainable use conservation unit created in 2001.It then flows through the eastern part of the Cazumbá-Iracema Extractive Reserve, established in 2002 to support sustainable use of the natural resources by the traditional population.