MYT1L explained

Myelin transcription factor 1 like is a protein that in humans is encoded by the MYT1L gene.^[1]

Function

This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017].

Further reading

• Vrijenhoek T, Buizer-Voskamp JE, van der Stelt I, Strengman E, Sabatti C, Geurts van Kessel A, Brunner HG, Ophoff RA, Veltman JA . Recurrent CNVs disrupt three candidate genes in schizophrenia patients . Am. J. Hum. Genet. . 83 . 4 . 504–10 . 2008 . 18940311 . 2561936 . 10.1016/j.ajhg.2008.09.011 .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Wang T, Zeng Z, Li T, Liu J, Li J, Li Y, Zhao Q, Wei Z, Wang Y, Li B, Feng G, He L, Shi Y . Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population . PLOS ONE . 5 . 10 . e13662 . 2010 . 21048971 . 2965102 . 10.1371/journal.pone.0013662 . 2010PLoSO...513662W . free .
• Wang T, Zeng Z, Li T, Liu J, Li J, Li Y, Zhao Q, Wei Z, Wang Y, Li B, Feng G, He L, Shi Y . Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population . PLOS ONE . 5 . 10 . e13662 . 2010 . 21048971 . 2965102 . 10.1371/journal.pone.0013662 . 2010PLoSO...513662W . free .
• Li W, Wang X, Zhao J, Lin J, Song XQ, Yang Y, Jiang C, Xiao B, Yang G, Zhang HX, Lv LX . Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population . Genes Brain Behav. . 11 . 1 . 87–93 . 2012 . 21923761 . 10.1111/j.1601-183X.2011.00734.x . 2280688 . free .
• Stevens SJ, van Ravenswaaij-Arts CM, Janssen JW, Klein Wassink-Ruiter JS, van Essen AJ, Dijkhuizen T, van Rheenen J, Heuts-Vijgen R, Stegmann AP, Smeets EE, Engelen JJ . MYT1L is a candidate gene for intellectual disability in patients with 2p25.3 (2pter) deletions . Am. J. Med. Genet. A . 155A . 11 . 2739–45 . 2011 . 21990140 . 10.1002/ajmg.a.34274 . 19484566 .
• Meyer KJ, Axelsen MS, Sheffield VC, Patil SR, Wassink TH . Germline mosaic transmission of a novel duplication of PXDN and MYT1L to two male half-siblings with autism . Psychiatr. Genet. . 22 . 3 . 137–40 . 2012 . 22157634 . 3309069 . 10.1097/YPG.0b013e32834dc3f5 .
• Lee Y, Mattai A, Long R, Rapoport JL, Gogtay N, Addington AM . Microduplications disrupting the MYT1L gene (2p25.3) are associated with schizophrenia . Psychiatr. Genet. . 22 . 4 . 206–9 . 2012 . 22547139 . 3384746 . 10.1097/YPG.0b013e328353ae3d .
• Rio M, Royer G, Gobin S, de Blois MC, Ozilou C, Bernheim A, Nizon M, Munnich A, Bonnefont JP, Romana S, Vekemans M, Turleau C, Malan V . Monozygotic twins discordant for submicroscopic chromosomal anomalies in 2p25.3 region detected by array CGH . Clin. Genet. . 84 . 1 . 31–6 . 2013 . 23061379 . 10.1111/cge.12036 . 23829301 .

Notes and References

1. Web site: Entrez Gene: Myelin transcription factor 1 like. 2018-02-05.