MYO1G explained

Myosin IG, also known as myosin 1G and MYO1G, is a protein that in humans is encoded by the MYO1G gene.^[1] MYO1G is a member of class I unconventional myosins. Its expression is highly restricted to hematopoietic tissues and cells. It localises exclusively to the plasma membrane and is dependent on both the motor domain and the tail domain.^[2] MYO1G regulates cell elasticity possibly by interaction plasma membrane and cortical actin in Jurkat T-cells.

Function

MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010].

Further reading

• Patino-Lopez G, Aravind L, Dong X, Kruhlak MJ, Ostap EM, Shaw S . Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH) . J. Biol. Chem. . 285 . 12 . 8675–86 . March 2010 . 20071333 . 2838290 . 10.1074/jbc.M109.086959 . free .
• Larsen ME, Kornblit B, Larsen MV, Masmas TN, Nielsen M, Thiim M, Garred P, Stryhn A, Lund O, Buus S, Vindelov L . Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation . Biol. Blood Marrow Transplant. . 16 . 10 . 1370–81 . October 2010 . 20353833 . 10.1016/j.bbmt.2010.03.022 .
• Lio HY, Tang JL, Wu J, Wu SJ, Lin CY, Yang YC . Minor histocompatibility antigen HA-1 and HA-2 polymorphisms in Taiwan: frequency and application in hematopoietic stem cell transplantation . Clin. Chem. Lab. Med. . 48 . 9 . 1287–93 . September 2010 . 20509834 . 10.1515/CCLM.2010.246 . 32914575 .
• Sellami MH, Torjemane L, Espadas de Arias A, Kaabi H, Ladeb S, Ben Othman T, Poli F, Hmida S . Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs . Immunol. Invest. . 39 . 6 . 611–20 . 2010 . 20653428 . 10.3109/08820131003775029 . 38774267 .

Notes and References

1. Web site: Entrez Gene: Myosin IG. 2019-12-24.
2. Olety B, Wälte M, Honnert U, Schillers H, Bähler M . Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity . FEBS Letters . 584 . 3 . 493–9 . February 2010 . 19968988 . 10.1016/j.febslet.2009.11.096. 27557093 . free .,