| Myosin light chain kinase family, member 4 | |
| Caption: | The crystal structure of the human myosin light chain kinase Loc340156.[1] |
| Hgncid: | 27972 |
| Symbol: | MYLK4 |
| Entrezgene: | 340156 |
| Refseq: | NM_001012418 |
| Uniprot: | Q86YV6 |
| Ecnumber: | 2.7.11.18 |
| Chromosome: | 6 |
| Arm: | p |
| Band: | 25.2 |
Myosin light chain kinase 4 also known as MYLK4 is an enzyme which in humans is encoded by the MYLK2 gene.[2] MYLK4 is a member of the myosin light-chain kinase family of serine/threonine-specific protein kinases that phosphorylate the regulatory light chain of myosin II.[3]
This protein acts as an enzyme that catalyzes the following reaction: ATP + a protein -> ADP + a phosphoprotein.[4]
MYLK4 is also involved in protein amino acid phosphorylation meaning that it adds a phosphate group onto the molecule.[5]
Not very much is known about the specific functional characteristics of MLYK4, but it has recently been found that the gene may possibly have a role in having at least one driver mutation for cancer.[6] MYLK4 may also be involved in transferase activity, ATP binding, protein serine/threonine kinase activity, and also nucleotide binding.[7] Other names for MYLK4 are CaMLCK like; EG238564; MYLK4; Mylk4; Myosin light chain kinase family, member 4; SgK085; SGK085; Sgk085; Sugen kinase 85; Uncharacterized serine/threonine-protein kinase SgK085.[8]
There are other known myosin light-chain kinase enzymes.