MYH15 explained

Myosin-15 also known as myosin, heavy chain 15 is a protein that in humans is encoded by the MYH15 gene.^[1]

Function

MYH15 is a slow-twitch myosin.^[1]

Further reading

• Luke MM, O'Meara ES, Rowland CM, etal . Gene variants associated with ischemic stroke: the cardiovascular health study. . Stroke . 40 . 2 . 363–8 . 2009 . 19023099 . 2881155 . 10.1161/STROKEAHA.108.521328 .
• Rossi AC, Mammucari C, Argentini C, etal . Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles. . J. Physiol. . 588 . Pt 2 . 353–64 . 2010 . 19948655 . 10.1113/jphysiol.2009.181008 . 2821527 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Stedman HH, Kozyak BW, Nelson A, etal . Myosin gene mutation correlates with anatomical changes in the human lineage. . Nature . 428 . 6981 . 415–8 . 2004 . 15042088 . 10.1038/nature02358 . 2004Natur.428..415S . 4304466 .
• Nagase T, Ishikawa K, Suyama M, etal . Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 1 . 63–70 . 1999 . 10231032 . 10.1093/dnares/6.1.63 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• McGuigan K, Phillips PC, Postlethwait JH . Evolution of sarcomeric myosin heavy chain genes: evidence from fish. . Mol. Biol. Evol. . 21 . 6 . 1042–56 . 2004 . 15014174 . 10.1093/molbev/msh103 . free .
• Shiffman D, O'Meara ES, Bare LA, etal . Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. . Arterioscler. Thromb. Vasc. Biol. . 28 . 1 . 173–9 . 2008 . 17975119 . 10.1161/ATVBAHA.107.153981 . 2636623 .
• Bare LA, Morrison AC, Rowland CM, etal . Five common gene variants identify elevated genetic risk for coronary heart disease. . Genet. Med. . 9 . 10 . 682–9 . 2007 . 18073581 . 10.1097/GIM.0b013e318156fb62 . free .

Notes and References

1. Desjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH . Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family . Mol. Biol. Evol. . 19 . 4 . 375–93 . April 2002 . 11919279 . 10.1093/oxfordjournals.molbev.a004093. free .