MYH14 explained

Myosin-14 is a protein that in humans is encoded by the MYH14 gene.^{[1] [2] [3]}

This gene encodes a member of the myosin superfamily. Myosins are actin-dependent motor proteins with diverse functions, including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Chen AH, Ni L, Fukushima K, etal . Linkage of a gene for dominant non-syndromic deafness to chromosome 19 . Hum. Mol. Genet. . 4 . 6 . 1073–6 . 1995 . 7655461 . 10.1093/hmg/4.6.1073 .
• Shoeman RL, Sachse C, Höner B, etal . Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin . Am. J. Pathol. . 142 . 1 . 221–30 . 1993 . 8424456 . 1886840 .
• Xu XR, Huang J, Xu ZG, etal . Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver . Proc. Natl. Acad. Sci. U.S.A. . 98 . 26 . 15089–94 . 2002 . 11752456 . 10.1073/pnas.241522398 . 64988 . 2001PNAS...9815089X . free .
• Desjardins PR, Burkman JM, Shrager JB, etal . Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family . Mol. Biol. Evol. . 19 . 4 . 375–93 . 2002 . 11919279 . 10.1093/oxfordjournals.molbev.a004093. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Golomb E, Ma X, Jana SS, etal . Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family . J. Biol. Chem. . 279 . 4 . 2800–8 . 2004 . 14594953 . 10.1074/jbc.M309981200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wan D, Gong Y, Qin W, etal . Large-scale cDNA transfection screening for genes related to cancer development and progression . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 10.1073/pnas.0404089101 . 524842 . 2004PNAS..10115724W . free .
• Kim KY, Kovács M, Kawamoto S, etal . Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C . J. Biol. Chem. . 280 . 24 . 22769–75 . 2005 . 15845534 . 10.1074/jbc.M503488200 . free .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .

External links

• GeneReviews/NCBI/NIH/UW entry on Deafness and Hereditary Hearing Loss Overview

Notes and References

1. Leal A, Endele S, Stengel C, Huehne K, Loetterle J, Barrantes R, Winterpacht A, Rautenstrauss B . A novel myosin heavy chain gene in human chromosome 19q13.3 . Gene . 312 . 165–71 . Aug 2003 . 12909352 . 10.1016/S0378-1119(03)00613-9 .
2. Donaudy F, Snoeckx R, Pfister M, Zenner HP, Blin N, Di Stazio M, Ferrara A, Lanzara C, Ficarella R, Declau F, Pusch CM, Nurnberg P, Melchionda S, Zelante L, Ballana E, Estivill X, Van Camp G, Gasparini P, Savoia A . Nonmuscle Myosin Heavy-Chain Gene MYH14 Is Expressed in Cochlea and Mutated in Patients Affected by Autosomal Dominant Hearing Impairment (DFNA4) . Am J Hum Genet . 74 . 4 . 770–6 . Mar 2004 . 15015131 . 1181955 . 10.1086/383285 .
3. Web site: Entrez Gene: MYH14 myosin, heavy chain 14.