MYCL explained

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.^{[1] [2]}

MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.^[3]

Interactions

MYCL1 has been shown to interact with MAX.^{[4] [5]}

Further reading

• Lüscher B . Function and regulation of the transcription factors of the Myc/Max/Mad network . Gene . 277 . 1–2 . 1–14 . 2001 . 11602341 . 10.1016/S0378-1119(01)00697-7 .
• Ikegaki N, Minna J, Kennett RH . The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences . EMBO J. . 8 . 6 . 1793–9 . 1989 . 2548855 . 401025 . 10.1002/j.1460-2075.1989.tb03573.x.
• Kaye F, Battey J, Nau M, Brooks B, Seifter E, De Greve J, Birrer M, Sausville E, Minna J . Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing . Mol. Cell. Biol. . 8 . 1 . 186–95 . 1988 . 2827002 . 363100 . 10.1128/mcb.8.1.186.
• De Greve J, Battey J, Fedorko J, Birrer M, Evan G, Kaye F, Sausville E, Minna J . The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs . Mol. Cell. Biol. . 8 . 10 . 4381–8 . 1988 . 3054516 . 365511 . 10.1128/mcb.8.10.4381.
• DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW . The human myc gene family: structure and activity of L-myc and an L-myc pseudogene . Genes Dev. . 1 . 10 . 1311–1326 . 1988 . 3322939 . 10.1101/gad.1.10.1311 . free .
• Atchley WR, Fitch WM . Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner . Proc. Natl. Acad. Sci. U.S.A. . 92 . 22 . 10217–10221 . 1995 . 7479755 . 40767 . 10.1073/pnas.92.22.10217 . 1995PNAS...9210217A . free .
• FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE . Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc . Oncogene . 18 . 15 . 2489–2498 . 1999 . 10229200 . 10.1038/sj.onc.1202611 . free .
• Kumimoto H, Hamajima N, Nishimoto Y, Matsuo K, Shinoda M, Hatooka S, Ishizaki K . L-myc genotype is associated with different susceptibility to lung cancer in smokers . Jpn. J. Cancer Res. . 93 . 1 . 1–5 . 2002 . 11802801 . 10.1111/j.1349-7006.2002.tb01193.x . 5926866 .
• Suzuki H, Yamashiro K . L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma . Oncol. Rep. . 9 . 2 . 345–7 . 2002 . 11836605 . 10.3892/or.9.2.345 .
• Primdahl H, von der Maase H, Christensen M, Wolf H, Ørntoft TF . Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ . Oncol. Rep. . 9 . 3 . 551–5 . 2002 . 11956626 . 10.3892/or.9.3.551 .
• Demopoulos K, Arvanitis DA, Vassilakis DA, Siafakas NM, Spandidos DA . MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis . J. Cell. Mol. Med. . 6 . 2 . 215–222 . 2003 . 12169206 . 10.1111/j.1582-4934.2002.tb00188.x . 6740283 .
• Wu R, Lin L, Beer DG, Ellenson LH, Lamb BJ, Rouillard JM, Kuick R, Hanash S, Schwartz DR, Fearon ER, Cho KR . Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas . Am. J. Pathol. . 162 . 5 . 1603–10 . 2003 . 12707044 . 1851191 . 10.1016/S0002-9440(10)64294-0 .
• Kambara T, Sharp GB, Nagasaka T, Takeda M, Sasamoto H, Nakagawa H, Isozaki H, MacPhee DG, Jass JR, Tanaka N, Matsubara N . Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer . Clin. Cancer Res. . 10 . 5 . 1758–1763 . 2004 . 15014029 . 10.1158/1078-0432.CCR-0779-3 . free .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Spinola M, Falvella FS, Galvan A, Pignatiello C, Leoni VP, Pastorino U, Paroni R, Chen S, Skaug V, Haugen A, Dragani TA . Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival . Lung Cancer . 55 . 3 . 271–277 . 2007 . 17145094 . 10.1016/j.lungcan.2006.10.023 . 2434/25016 . free .

Notes and References

1. Speleman F, Van Camp G, Van Roy N . Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization . Cytogenet Cell Genet . 72 . 2–3 . 189–190 . Jan 1997 . 8978772 . 10.1159/000134185 .
2. Web site: Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian).
3. Ikegaki N, Minna J, Kennett RH . The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences . EMBO J. . 8 . 6 . 1793–9 . 1989 . 2548855 . 401025 . 10.1002/j.1460-2075.1989.tb03573.x.
4. Blackwood EM, Eisenman RN . Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc . . 251 . 4998 . 1211–1217 . Mar 1991 . 2006410 . 10.1126/science.2006410 . 1991Sci...251.1211B .
5. FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE . Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc . Oncogene . 18 . 15 . 2489–2498 . Apr 1999 . 10229200 . 10.1038/sj.onc.1202611 . free .