Mucin 7 Explained

Mucin-7 is a protein that in humans is encoded by the MUC7 gene.^{[1] [2]} In animals, the MUC7 gene is found in most placental mammals, but not marsupials.

Human variations

Humans carry either a five or six tandem repeat version of the gene. In other primates, the number of repeats found is 4-5 for gorillas, 5 for chimpanzees, 6-7 for orangutans, 8-10 for macaques, 10-11 for baboons and 11-12 for green monkeys.^[3]

Further reading

• Zalewska A, Zwierz K, Zółkowski K, Gindzieński A . Structure and biosynthesis of human salivary mucins . Acta Biochimica Polonica . 47 . 4 . 1067–79 . 2002 . 11996097 . 10.18388/abp.2000_3960. free .
• Bobek LA, Tsai H, Biesbrock AR, Levine MJ . Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7) . The Journal of Biological Chemistry . 268 . 27 . 20563–9 . September 1993 . 10.1016/S0021-9258(20)80762-5 . 7690757 . free .
• Troxler RF, Iontcheva I, Oppenheim FG, Nunes DP, Offner GD . Molecular characterization of a major high molecular weight mucin from human sublingual gland . Glycobiology . 7 . 7 . 965–73 . October 1997 . 9363439 . 10.1093/glycob/7.7.965 . free .
• Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ . Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity . Biochemistry . 37 . 14 . 4916–27 . April 1998 . 9538010 . 10.1021/bi972612a .
• Kirkbride HJ, Bolscher JG, Nazmi K, Vinall LE, Nash MW, Moss FM, Mitchell DM, Swallow DM . Genetic polymorphism of MUC7: allele frequencies and association with asthma . European Journal of Human Genetics . 9 . 5 . 347–54 . May 2001 . 11378823 . 10.1038/sj.ejhg.5200642 . free .
• Guo JM, Zhang Y, Cheng L, Iwasaki H, Wang H, Kubota T, Tachibana K, Narimatsu H . Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12 . FEBS Letters . 524 . 1–3 . 211–8 . July 2002 . 12135769 . 10.1016/S0014-5793(02)03007-7 . 84453381 . free .
• Cheng L, Tachibana K, Zhang Y, Guo J, Kahori Tachibana K, Kameyama A, Wang H, Hiruma T, Iwasaki H, Togayachi A, Kudo T, Narimatsu H . Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10 . FEBS Letters . 531 . 2 . 115–21 . November 2002 . 12417297 . 10.1016/S0014-5793(02)03399-9 . 221288147 .
• Banderas-Tarabay JA, Zacarías-D'Oleire IG, Garduño-Estrada R, Aceves-Luna E, González-Begné M . Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students . Archives of Medical Research . 33 . 5 . 499–505 . 2003 . 12459324 . 10.1016/S0188-4409(02)00395-8 .
• Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H . Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14 . Biochemical and Biophysical Research Communications . 300 . 3 . 738–44 . January 2003 . 12507512 . 10.1016/S0006-291X(02)02908-X .
• Soares RV, Siqueira CC, Bruno LS, Oppenheim FG, Offner GD, Troxler RF . MG2 and lactoferrin form a heterotypic complex in salivary secretions . Journal of Dental Research . 82 . 6 . 471–5 . June 2003 . 12766201 . 10.1177/154405910308200613 . 23276142 .
• Ge J, Catt DM, Gregory RL . Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen . Infection and Immunity . 72 . 11 . 6748–52 . November 2004 . 15501816 . 523000 . 10.1128/IAI.72.11.6748-6752.2004 .
• Grys TE, Siegel MB, Lathem WW, Welch RA . The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells . Infection and Immunity . 73 . 3 . 1295–303 . March 2005 . 15731026 . 1064933 . 10.1128/IAI.73.3.1295-1303.2005 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD . Two-hybrid analysis of human salivary mucin MUC7 interactions . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1746 . 1 . 65–72 . October 2005 . 16203048 . 10.1016/j.bbamcr.2005.08.007 .
• Li S, Intini G, Bobek LA . Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo . American Journal of Respiratory Cell and Molecular Biology . 35 . 1 . 95–102 . July 2006 . 16514118 . 2658701 . 10.1165/rcmb.2005-0305OC .

Notes and References

1. Bobek LA, Liu J, Sait SN, Shows TB, Bobek YA, Levine MJ . Structure and chromosomal localization of the human salivary mucin gene, MUC7 . Genomics . 31 . 3 . 277–82 . February 1996 . 8838308 . 10.1006/geno.1996.0049 .
2. Web site: Entrez Gene: MUC7 mucin 7, secreted.
3. Xu D, Pavlidis P, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O . Recent evolution of the salivary mucin MUC7 . Scientific Reports . 6 . 31791 . August 2016 . 27558399 . 4997351 . 10.1038/srep31791 . 2016NatSR...631791X . This article contains quotations from this source, which is available under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.