Mucin 5AC explained

Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans.^{[1] [2] [3]}

MUC-5AC is a large gel-forming glycoprotein. In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance. Overproduction of MUC-5AC can contribute to diseases such as asthma and chronic obstructive pulmonary disease,^[4] and has also been associated with greater protection against influenza infection.^[5]

Clinical relevance

This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD).^[6]

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Mucin-5AC

Notes and References

1. Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N . Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes? . Biochem J . 305 . Pt 1. 211–9 . Feb 1995 . 7826332 . 1136451 . 10.1042/bj3050211.
2. van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW . Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif . Biochem Biophys Res Commun . 245 . 3 . 853–9 . Jun 1998 . 9588204 . 10.1006/bbrc.1998.8535 .
3. Web site: Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming.
4. Samsuzzaman M, Uddin MS, Shah MA, Mathew B . Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production . Life Sciences . 231 . 116485 . August 2019 . 31116959 . 10.1016/j.lfs.2019.05.041 . 162182150 .
5. Ehre. Camille. Worthington. Erin N.. Liesman. Rachael M.. Grubb. Barbara R.. Barbier. Diane. O'Neal. Wanda K.. Sallenave. Jean-Michel. Pickles. Raymond J.. Boucher. Richard C.. 2012-10-09. Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs. Proceedings of the National Academy of Sciences of the United States of America. 109. 41. 16528–16533. 10.1073/pnas.1206552109. 1091-6490. 3478656. 23012413. 2012PNAS..10916528E . free.
6. Li J, Ye Z . The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease . Molecules . Basel, Switzerland . 25 . 19 . September 2020 . 4437 . 32992527 . 7582261 . 10.3390/molecules25194437 . free .