MTX1 explained

Metaxin 1, also known as MTX1, is a protein which in humans is encoded by the MTX1 gene.^{[1] [2]}

Function

The metaxin gene, which encodes a protein located on the outer membrane of mitochondria, is a component of the mitochondrial protein translocation apparatus.^[3]

Further reading

• Bornstein P . Metaxin, a gene contiguous to both thrombospondin 3 and glucocerebrosidase, is required for embryonic development in the mouse: implications for Gaucher disease . Proc. Natl. Acad. Sci. U.S.A. . 92 . 10 . 4547–51 . 1995 . 7753840 . 10.1073/pnas.92.10.4547 . 41981 . vanc. McKinney CE . LaMarca ME . 3 . Winfield . S . Shingu . T . Devarayalu . S . Vos . HL . Ginns . EI . 1995PNAS...92.4547B . free .
• Long GL . Structure and organization of the human metaxin gene (MTX) and pseudogene . Genomics . 33 . 2 . 177–84 . 1997 . 8660965 . 10.1006/geno.1996.0181 . vanc. Winfield S . Adolph KW . 3 . Ginns . Edward I. . Bornstein . Paul .
• Armstrong LC . Metaxin is a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion . J. Biol. Chem. . 272 . 10 . 6510–8 . 1997 . 9045676 . 10.1074/jbc.272.10.6510 . vanc. Komiya T . Bergman BE . 3 . Mihara . K . Bornstein . P . free.
• Winfield SL . Identification of Three Additional Genes Contiguous to the Glucocerebrosidase Locus on Chromosome 1q21: Implications for Gaucher Disease . Genome Res. . 7 . 10 . 1020–6 . 1997 . 9331372 . 10.1101/gr.7.10.1020 . 310674 . vanc. Tayebi N . Martin BM . 3 . Ginns . EI . Sidransky . E .
• Armstrong LC, Saenz AJ, Bornstein P . Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane . J. Cell. Biochem. . 74 . 1 . 11–22 . 1999 . 10381257 . 10.1002/(SICI)1097-4644(19990701)74:1<11::AID-JCB2>3.0.CO;2-V . 38802766 .
• Abdul KM . Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex . Biochem. Biophys. Res. Commun. . 276 . 3 . 1028–34 . 2000 . 11027586 . 10.1006/bbrc.2000.3589 . vanc. Terada K . Yano M . 3 . Ryan . Michael T. . Streimann . Illo . Hoogenraad . Nicholas J. . Mori . Masataka .
• Wang X . Metaxin is required for tumor necrosis factor-induced cell death . EMBO Rep. . 2 . 7 . 628–33 . 2001 . 11454742 . 10.1093/embo-reports/kve135 . 1083949 . vanc. Ono K . Kim SO . 3 . Kravchenko . Vladimir . Lin . Sheng-Cai . Han . Jiahuai .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• LaMarca ME . A novel alteration in metaxin 1, F202L, is associated with N370S in Gaucher disease . J. Hum. Genet. . 49 . 4 . 220–2 . 2004 . 15024629 . 10.1007/s10038-004-0134-7 . vanc. Goldstein M . Tayebi N . 3 . Arcos-Burgos . Mauricio . Martin . Brian M. . Sidransky . Ellen . free.
• Ewing RM . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . vanc. Chu P . Elisma F . 3 . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .
• Kozjak-Pavlovic V . Conserved roles of Sam50 and metaxins in VDAC biogenesis . EMBO Rep. . 8 . 6 . 576–82 . 2007 . 17510655 . 10.1038/sj.embor.7400982 . 2002532 . vanc. Ross K . Benlasfer N . 3 . Kimmig . Sonja . Karlas . Alexander . Rudel . Thomas .
• Xie J . The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11 . FEBS Lett. . 581 . 18 . 3545–9 . 2007 . 17624330 . 10.1016/j.febslet.2007.06.052 . vanc. Marusich MF . Souda P . 3 . Whitelegge . Julian . Capaldi . Roderick A. . free .

Notes and References

1. Web site: Entrez Gene: MTX1 metaxin 1.
2. Bornstein P, McKinney CE, LaMarca ME, Winfield S, Shingu T, Devarayalu S, Vos HL, Ginns EI . Metaxin, a gene contiguous to both thrombospondin 3 and glucocerebrosidase, is required for embryonic development in the mouse: implications for Gaucher disease . Proc. Natl. Acad. Sci. U.S.A. . 92 . 10 . 4547–51 . May 1995 . 7753840 . 41981 . 10.1073/pnas.92.10.4547. 1995PNAS...92.4547B . free .
3. Armstrong LC, Komiya T, Bergman BE, Mihara K, Bornstein P . Metaxin is a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion . J. Biol. Chem. . 272 . 10 . 6510–8 . March 1997 . 9045676 . 10.1074/jbc.272.10.6510 . free .