MTMR6 explained

Myotubularin-related protein 6 is a protein that in humans is encoded by the MTMR6 gene.^{[1] [2]}

Interactions

MTMR6 has been shown to interact with MTMR9.^[3]

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2000 . 11256614 . 1083732 . 10.1093/embo-reports/kvd058 .
• Schaletzky J, Dove SK, Short B, Lorenzo O, Clague MJ, Barr FA . Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases . Curr. Biol. . 13 . 6 . 504–9 . 2003 . 12646134 . 10.1016/S0960-9822(03)00132-5 . free . 2003CBio...13..504S .
• Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA . Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP . Proc. Natl. Acad. Sci. U.S.A. . 100 . 15 . 8660–5 . 2003 . 12847286 . 166368 . 10.1073/pnas.1033097100 . 2003PNAS..100.8660N . free .
• Mochizuki Y, Majerus PW . Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 . Proc. Natl. Acad. Sci. U.S.A. . 100 . 17 . 9768–73 . 2003 . 12890864 . 187840 . 10.1073/pnas.1333958100 . 2003PNAS..100.9768M . free .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .
• Srivastava S, Ko K, Choudhury P, Li Z, Johnson AK, Nadkarni V, Unutmaz D, Coetzee WA, Skolnik EY . Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells . Mol. Cell. Biol. . 26 . 15 . 5595–602 . 2006 . 16847315 . 1592754 . 10.1128/MCB.00352-06 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Myotubularin-related protein 6 (MTMR6)

Notes and References

1. Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL . Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human . Hum. Mol. Genet. . 7 . 11 . 1703–12 . Dec 1998 . 9736772 . 10.1093/hmg/7.11.1703 . free .
2. Web site: Entrez Gene: MTMR6 myotubularin related protein 6.
3. Mochizuki Y, Majerus PW . Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 . Proc. Natl. Acad. Sci. U.S.A. . 100 . 17 . 9768–73 . Aug 2003 . 12890864 . 187840 . 10.1073/pnas.1333958100 . 2003PNAS..100.9768M . free .