MTCP1 explained

Protein p13 MTCP-1 is a protein that in humans is encoded by the MTCP1 gene.^{[1] [2] [3] [4]}

Function

This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. The gene has two ORFs that encode two different proteins. The upstream ORF encodes a 13kDa protein that is a member of the TCL1 family; this protein may be involved in leukemogenesis. The downstream ORF encodes an 8kDa protein that localizes to mitochondria. Alternative splicing results in multiple transcript variants.

Interactions

MTCP1 has been shown to interact with AKT1.^{[5] [6]}

Further reading

• Kenwrick S, Levinson B, Taylor S, Shapiro A, Gitschier J . Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene . Hum. Mol. Genet. . 1 . 3 . 179–86 . 1993 . 1303175 . 10.1093/hmg/1.3.179 .
• Madani A, Soulier J, Schmid M, Plichtova R, Lermé F, Gateau-Roesch O, Garnier JP, Pla M, Sigaux F, Stern MH . The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein . Oncogene . 10 . 11 . 2259–62 . 1995 . 7784073 .
• Soulier J, Madani A, Cacheux V, Rosenzwajg M, Sigaux F, Stern MH . The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation . Oncogene . 9 . 12 . 3565–70 . 1994 . 7970717 .
• Thick J, Mak YF, Metcalfe J, Beatty D, Taylor AM . A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia . Leukemia . 8 . 4 . 564–73 . 1994 . 8152252 .
• Fisch P, Forster A, Sherrington PD, Dyer MJ, Rabbitts TH . The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another . Oncogene . 8 . 12 . 3271–6 . 1993 . 8247530 .
• Gritti C, Choukroun V, Soulier J, Madani A, Dastot H, Leblond V, Radford-Weiss I, Valensi F, Varet B, Sigaux F, Stern MH . Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations . Oncogene . 15 . 11 . 1329–35 . 1997 . 9315101 . 10.1038/sj.onc.1201303 . free .
• Barthe P, Yang YS, Chiche L, Hoh F, Strub MP, Guignard L, Soulier J, Stern MH, van Tilbeurgh H, Lhoste JM, Roumestand C . Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif . J. Mol. Biol. . 274 . 5 . 801–15 . 1998 . 9405159 . 10.1006/jmbi.1997.1438 .
• Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Varnum J, Germann MW, Croce CM . Purification and characterization of recombinant forms of TCL-1 and MTCP-1 proteins . Protein Expr. Purif. . 12 . 2 . 215–25 . 1998 . 9518463 . 10.1006/prep.1997.0822 .
• Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW . Crystal structure of MTCP-1: Implications for role of TCL-1 and MTCP-1 in T cell malignancies . Proc. Natl. Acad. Sci. U.S.A. . 95 . 7 . 3413–8 . 1998 . 9520380 . 19850 . 10.1073/pnas.95.7.3413 . 1998PNAS...95.3413F . free .
• Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C . Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data . J. Biomol. NMR . 17 . 3 . 215–30 . 2000 . 10959629 . 10.1023/A:1008386110930 . 46115803 .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 310948 . 10.1101/gr.143000 .
• Laine J, Künstle G, Obata T, Noguchi M . Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family . J. Biol. Chem. . 277 . 5 . 3743–51 . 2002 . 11707444 . 10.1074/jbc.M107069200 . free .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .

Notes and References

1. Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A, Sigaux F, Kirsch IR . MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations . Oncogene . 8 . 9 . 2475–83 . September 1993 . 8361760 .
2. Madani A, Choukroun V, Soulier J, Cacheux V, Claisse JF, Valensi F, Daliphard S, Cazin B, Levy V, Leblond V, Daniel MT, Sigaux F, Stern MH . Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations . Blood . 87 . 5 . 1923–7 . July 1996 . 8634440 . 10.1182/blood.V87.5.1923.1923. free .
3. Yang YS, Guignard L, Padilla A, Hoh F, Strub MP, Stern MH, Lhoste JM, Roumestand C . Solution structure of the recombinant human oncoprotein p13MTCP1 . J Biomol NMR . 11 . 3 . 337–54 . September 1998 . 9691281 . 10.1023/A:1008279616063 . 22862333 .
4. Web site: Entrez Gene: MTCP1 mature T-cell proliferation 1.
5. Laine J, Künstle G, Obata T, Noguchi M . Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family . J. Biol. Chem. . 277 . 5 . 3743–51 . February 2002 . 11707444 . 10.1074/jbc.M107069200 . free .
6. Laine J, Künstle G, Obata T, Sha M, Noguchi M . The protooncogene TCL1 is an Akt kinase coactivator . Mol. Cell . 6 . 2 . 395–407 . August 2000 . 10983986 . 10.1016/S1097-2765(00)00039-3 . free .