MSRB2 explained

Methionine-R-sulfoxide reductase B2, mitochondrial is an enzyme that in humans is encoded by the MSRB2 gene.^{[1] [2] [3]} The MRSB2 enzyme catalyzes the reduction of methionine sulfoxide to methionine.

See also

• MSRA (gene)
• Methionine oxidation
• SEPX1

Further reading

• Lai CH, Chou CY, Ch'ang LY, etal . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Res. . 10 . 5 . 703–13 . 2000 . 10810093 . 10.1101/gr.10.5.703 . 310876 .
• Jung S, Hansel A, Kasperczyk H, etal . Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1 . FEBS Lett. . 527 . 1–3 . 91–4 . 2002 . 12220640 . 10.1016/S0014-5793(02)03171-X . 2170229 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Kim HY, Gladyshev VN . Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases . Mol. Biol. Cell . 15 . 3 . 1055–64 . 2004 . 14699060 . 10.1091/mbc.E03-08-0629 . 363075 .
• Picot CR, Perichon M, Cintrat JC, etal . The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts . FEBS Lett. . 558 . 1–3 . 74–8 . 2004 . 14759519 . 10.1016/S0014-5793(03)01530-8 . 32573388 .
• Hansel A, Jung S, Hoshi T, Heinemann SH . A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1 . Redox Rep. . 8 . 6 . 384–8 . 2004 . 14980072 . 10.1179/135100003225003429 . free .
• Schallreuter KU, Rübsam K, Chavan B, etal . Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus . Biochem. Biophys. Res. Commun. . 342 . 1 . 145–52 . 2006 . 16480945 . 10.1016/j.bbrc.2006.01.124 .

Notes and References

1. Escribano J, Ortego J, Coca-Prados M . Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins . J Biochem . 118 . 5 . 921–31 . Jan 1997 . 8749308 . 10.1093/jb/118.5.921.
2. Huang W, Escribano J, Sarfarazi M, Coca-Prados M . Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases . Gene . 233 . 1–2 . 233–40 . Aug 1999 . 10375640 . 10.1016/S0378-1119(99)00131-6 . free .
3. Web site: Entrez Gene: MSRB2 methionine sulfoxide reductase B2.