MSC (gene) explained

Musculin is a protein that in humans is encoded by the MSC gene.^{[1] [2] [3]}

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Robb L, Hartley L, Wang CC, etal . musculin: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle . Mech. Dev. . 76 . 1–2 . 197–201 . 1998 . 9767165 . 10.1016/S0925-4773(98)00122-1 . 780834 . free .
• Wong J, Funes-Duran M, Ahlberg J, etal . Characterization of a basic helix-loop-helix protein, ABF-1: nuclear localization, transcriptional properties, and interaction with Id-2 . DNA Cell Biol. . 20 . 8 . 465–71 . 2001 . 11560778 . 10.1089/104454901316976091 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Knight JC, Keating BJ, Kwiatkowski DP . Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1 . Nat. Genet. . 36 . 4 . 394–9 . 2004 . 15052269 . 10.1038/ng1331 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .

Notes and References

1. Massari ME, Rivera RR, Voland JR, Quong MW, Breit TM, van Dongen JJ, de Smit O, Murre C . Characterization of ABF-1, a Novel Basic Helix-Loop-Helix Transcription Factor Expressed in Activated B Lymphocytes . Mol Cell Biol . 18 . 6 . 3130–9 . Jun 1998 . 9584154 . 108895 . 10.1128/mcb.18.6.3130.
2. Robb L, Brodnicki T, Copeland NG, Gilbert DJ, Jenkins NA, Harvey RP . Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1 . Genomics . 57 . 2 . 318–9 . May 1999 . 10198176 . 10.1006/geno.1999.5764 .
3. Web site: Entrez Gene: MSC musculin (activated B-cell factor-1).