MS4A2 explained

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.^{[1] [2]}

Function

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.^[2]

See also

• FcεRI

Further reading

• Jouvin MH, Numerof RP, Kinet JP . Signal transduction through the conserved motifs of the high affinity IgE receptor Fc epsilon RI. . Semin. Immunol. . 7 . 1 . 29–35 . 1995 . 7612892 . 10.1016/1044-5323(95)90005-5 .
• Wilson BS, Pfeiffer JR, Oliver JM . FcepsilonRI signaling observed from the inside of the mast cell membrane. . Mol. Immunol. . 38 . 16–18 . 1259–68 . 2003 . 12217393 . 10.1016/S0161-5890(02)00073-1 .
• Kraft S, Rana S, Jouvin MH, Kinet JP . The role of the FcepsilonRI beta-chain in allergic diseases. . Int. Arch. Allergy Immunol. . 135 . 1 . 62–72 . 2004 . 15316148 . 10.1159/000080231 . 83898946 .
• Bieber T, de la Salle H, Wollenberg A, etal . Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI). . J. Exp. Med. . 175 . 5 . 1285–90 . 1992 . 1533242 . 10.1084/jem.175.5.1285 . 2119213 .
• Küster H, Zhang L, Brini AT, etal . The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor. . J. Biol. Chem. . 267 . 18 . 12782–7 . 1992 . 10.1016/S0021-9258(18)42344-7 . 1535625 . free .
• Le Coniat M, Kinet JP, Berger R . The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23. . Immunogenetics . 32 . 3 . 183–6 . 1990 . 2146219 . 10.1007/BF02114971 . 23874749 .
• Tedder TF, Streuli M, Schlossman SF, Saito H . Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. . Proc. Natl. Acad. Sci. U.S.A. . 85 . 1 . 208–12 . 1988 . 2448768 . 10.1073/pnas.85.1.208 . 279513 . 1988PNAS...85..208T . free .
• Paolini R, Renard V, Vivier E, etal . Different roles for the Fc epsilon RI gamma chain as a function of the receptor context. . J. Exp. Med. . 181 . 1 . 247–55 . 1995 . 7528770 . 10.1084/jem.181.1.247 . 2191817 .
• Shirakawa T, Li A, Dubowitz M, etal . Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. . Nat. Genet. . 7 . 2 . 125–9 . 1994 . 7920628 . 10.1038/ng0694-125 . 24026689 .
• Kihara H, Siraganian RP . Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor. . J. Biol. Chem. . 269 . 35 . 22427–32 . 1994 . 10.1016/S0021-9258(17)31807-0 . 8071371 . free .
• Sandford AJ, Shirakawa T, Moffatt MF, etal . Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. . Lancet . 341 . 8841 . 332–4 . 1993 . 8094113 . 10.1016/0140-6736(93)90136-5 . 54428682 .
• Szepetowski P, Gaudray P . FCER1B, a candidate gene for atopy, is located in 11q13 between CD20 and TCN1. . Genomics . 19 . 2 . 399–400 . 1994 . 8188278 . 10.1006/geno.1994.1083 .
• Daniels SE, Bhattacharrya S, James A, etal . A genome-wide search for quantitative trait loci underlying asthma. . Nature . 383 . 6597 . 247–50 . 1996 . 8805698 . 10.1038/383247a0 . 1996Natur.383..247D . 22256638 .
• Hill MR, Cookson WO . A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. . Hum. Mol. Genet. . 5 . 7 . 959–62 . 1997 . 8817330 . 10.1093/hmg/5.7.959 . free .
• Shirakawa T, Mao XQ, Sasaki S, etal . Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. . Hum. Mol. Genet. . 5 . 8 . 1129–30 . 1997 . 8842731 . 10.1093/hmg/5.8.1129 . free .
• Shirakawa T, Mao XQ, Sasaki S, etal . Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. . Hum. Mol. Genet. . 5 . 12 . 2068 . 1997 . 8968765 .
• Hendricks-Taylor LR, Motto DG, Zhang J, etal . SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. . J. Biol. Chem. . 272 . 2 . 1363–7 . 1997 . 8995445 . 10.1074/jbc.272.2.1363 . free .
• Kanzaki M, Lindorfer MA, Garrison JC, Kojima I . Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein. . J. Biol. Chem. . 272 . 23 . 14733–9 . 1997 . 9169438 . 10.1074/jbc.272.23.14733 . free .

Notes and References

1. Maekawa K, Imagawa N, Tanaka Y, Harada S . Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor . FEBS Lett . 302 . 2 . 161–5 . Aug 1992 . 1386024 . 10.1016/0014-5793(92)80430-O . 44791683 . free .
2. Web site: Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide).