MRS-1706 explained

MRS-1706 is a selective inverse agonist for the adenosine A2B receptor.[1] It inhibits release of interleukins and has an antiinflammatory effect.[2] [3]

Notes and References

  1. Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW . ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor . The Journal of Pharmacology and Experimental Therapeutics . 320 . 2 . 637–45 . February 2007 . 17077318 . 10.1124/jpet.106.111203 .
  2. Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D . Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study . Journal of Neurochemistry . 105 . 3 . 904–9 . May 2008 . 18088370 . 10.1111/j.1471-4159.2007.05191.x . free .
  3. Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, Biaggioni I, Feoktistov I . 6 . Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells . Journal of Immunology . 180 . 11 . 7212–20 . June 2008 . 18490720 . 3628765. 10.4049/jimmunol.180.11.7212 . free .

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