MRPS5 explained
28S ribosomal protein S5, mitochondrial, otherwise called uS5m, is a protein that in humans is encoded by the MRPS5 gene.[1]
Function
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q.
Further reading
- Zhang Z, Gerstein M . Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome . Genomics . 81 . 5 . 468–80 . May 2003 . 12706105 . 10.1016/S0888-7543(03)00004-1 .
- Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T . The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders . Genomics . 77 . 1–2 . 65–70 . Sep 2001 . 11543634 . 10.1006/geno.2001.6622 .
- Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K . Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit . The Journal of Biological Chemistry . 276 . 35 . 33181–95 . Aug 2001 . 11402041 . 10.1074/jbc.M103236200 . free .
- Koc EC, Burkhart W, Blackburn K, Koc H, Moseley A, Spremulli LL . Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach . Protein Science . 10 . 3 . 471–81 . Mar 2001 . 11344316 . 2374141 . 10.1110/ps.35301 .
- Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL . The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present . The Journal of Biological Chemistry . 276 . 22 . 19363–74 . Jun 2001 . 11279123 . 10.1074/jbc.M100727200 . free . 10.1.1.501.8919 .
Notes and References
- Web site: Entrez Gene: MRPS5 mitochondrial ribosomal protein S5.
