M-RIP explained

Myosin phosphatase Rho-interacting protein is an enzyme that in humans is encoded by the MPRIP gene.^{[1] [2]}

Interactions

M-RIP has been shown to interact with RHOA.^[3]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH . Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. . J. Cell Biol. . 137 . 7 . 1603–13 . 1997 . 9199174 . 2137826 . 10.1083/jcb.137.7.1603 .
• Surks HK, Richards CT, Mendelsohn ME . Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. . J. Biol. Chem. . 278 . 51 . 51484–93 . 2004 . 14506264 . 10.1074/jbc.M305622200 . free .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
• Mulder J, Ariaens A, van den Boomen D, Moolenaar WH . p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesis. . Mol. Biol. Cell . 15 . 12 . 5516–27 . 2005 . 15469989 . 532030 . 10.1091/mbc.E04-04-0275 .
• Koga Y, Ikebe M . p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA. . J. Biol. Chem. . 280 . 6 . 4983–91 . 2005 . 15545284 . 10.1074/jbc.M410909200 . free .
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Surks HK, Riddick N, Ohtani K . M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. . J. Biol. Chem. . 280 . 52 . 42543–51 . 2006 . 16257966 . 10.1074/jbc.M506863200 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 5 . 6 . 355–64 . May 1999 . 10048485 . 10.1093/dnares/5.6.355 . free .
2. Web site: Entrez Gene: M-RIP myosin phosphatase-Rho interacting protein.
3. Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH . Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology . J. Cell Biol. . 137 . 7 . 1603–13 . Jun 1997 . 9199174 . 2137826 . 10.1083/jcb.137.7.1603 .