MPP5 explained

MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene.^{[1] [2]} Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM]^[3]

Interactions

MPP5 has been shown to interact with INADL and FAM71D.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, etal . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
• Kamberov E, Makarova O, Roh M, etal . Molecular cloning and characterization of Pals, proteins associated with mLin-7. . J. Biol. Chem. . 275 . 15 . 11425–31 . 2000 . 10753959 . 10.1074/jbc.275.15.11425 . free .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Simpson JC, Wellenreuther R, Poustka A, etal . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 .
• Tseng TC, Marfatia SM, Bryant PJ, etal . VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain. . Biochim. Biophys. Acta . 1518 . 3 . 249–59 . 2001 . 11311936 . 10.1016/s0167-4781(01)00191-9.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Makarova O, Roh MH, Liu CJ, etal . Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). . Gene . 302 . 1–2 . 21–9 . 2003 . 12527193 . 10.1016/S0378111902010843 .
• Hurd TW, Gao L, Roh MH, etal . Direct interaction of two polarity complexes implicated in epithelial tight junction assembly . Nat. Cell Biol. . 5 . 2 . 137–42 . 2003 . 12545177 . 10.1038/ncb923 . 25212419 .
• Roh MH, Fan S, Liu CJ, Margolis B . The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells . J. Cell Sci. . 116 . Pt 14 . 2895–906 . 2004 . 12771187 . 10.1242/jcs.00500 . 4482921 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Penkert RR, DiVittorio HM, Prehoda KE . Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex . Nat. Struct. Mol. Biol. . 11 . 11 . 1122–7 . 2004 . 15475968 . 10.1038/nsmb839 . 2140275 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Stöhr H, Molday LL, Molday RS, etal . Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina . J. Comp. Neurol. . 481 . 1 . 31–41 . 2005 . 15558731 . 10.1002/cne.20367 . 19904556 .
• Feng W, Long JF, Zhang M . A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins . Proc. Natl. Acad. Sci. U.S.A. . 102 . 19 . 6861–6 . 2005 . 15863617 . 10.1073/pnas.0409346102 . 1100767 . 2005PNAS..102.6861F . free .
• Kantardzhieva A, Gosens I, Alexeeva S, etal . MPP5 recruits MPP4 to the CRB1 complex in photoreceptors . Invest. Ophthalmol. Vis. Sci. . 46 . 6 . 2192–201 . 2005 . 15914641 . 10.1167/iovs.04-1417 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .

Notes and References

1. Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B . The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost . J Cell Biol . 157 . 1 . 161–72 . Apr 2002 . 11927608 . 2173254 . 10.1083/jcb.200109010 .
2. Web site: Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5).
3. Web site: Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5).