MPP1 explained

55 kDa erythrocyte membrane protein is a protein that in humans is encoded by the MPP1 gene.^{[1] [2]}

Palmitoylated membrane protein 1 is the prototype of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 1 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.

Further reading

• Metzenberg AB, Gitschier J . The gene encoding the palmitoylated erythrocyte membrane protein, p55, originates at the CpG island 3' to the factor VIII gene . Hum. Mol. Genet. . 1 . 2 . 97–101 . 1993 . 1301163 . 10.1093/hmg/1.2.97 .
• Bryant PJ, Woods DF . A major palmitoylated membrane protein of human erythrocytes shows homology to yeast guanylate kinase and to the product of a Drosophila tumor suppressor gene . Cell . 68 . 4 . 621–2 . 1992 . 1310897 . 10.1016/0092-8674(92)90136-Z . 46607652 .
• Marfatia SM, Leu RA, Branton D, Chishti AH . Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein . J. Biol. Chem. . 270 . 2 . 715–9 . 1995 . 7822301 . 10.1074/jbc.270.2.715 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Kim AC, Metzenberg AB, Sahr KE, etal . Complete genomic organization of the human erythroid p55 gene (MPP1), a membrane-associated guanylate kinase homologue . Genomics . 31 . 2 . 223–9 . 1997 . 8824805 . 10.1006/geno.1996.0035 .
• Marfatia SM, Morais-Cabral JH, Kim AC, etal . The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis . J. Biol. Chem. . 272 . 39 . 24191–7 . 1997 . 9305870 . 10.1074/jbc.272.39.24191 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Simpson JC, Wellenreuther R, Poustka A, etal . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Stelzl U, Worm U, Lalowski M, etal . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kusunoki H, Kohno T . Solution structure of human erythroid p55 PDZ domain . Proteins . 64 . 3 . 804–7 . 2006 . 16741958 . 10.1002/prot.21028 . 37573998 .
• Gosens I, van Wijk E, Kersten FF, etal . MPP1 links the Usher protein network and the Crumbs protein complex in the retina . Hum. Mol. Genet. . 16 . 16 . 1993–2003 . 2007 . 17584769 . 10.1093/hmg/ddm147 . free .

Notes and References

1. Ruff P, Speicher DW, Husain-Chishti A . Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif . Proc Natl Acad Sci U S A . 88 . 15 . 6595–9 . Sep 1991 . 1713685 . 52133 . 10.1073/pnas.88.15.6595 . 1991PNAS...88.6595R . free .
2. Web site: Entrez Gene: MPP1 membrane protein, palmitoylated 1, 55kDa.