MPDZ explained

Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.^[1]

Interactions

MPDZ has been shown to interact with:

• 5-HT2C receptor,^{[2] [3]}
• CD117,^[4] and
• PLEKHA1.^[5]

Further reading

• Ullmer C, Schmuck K, Figge A, Lübbert H . Cloning and characterization of MUPP1, a novel PDZ domain protein . FEBS Lett. . 424 . 1–2 . 63–8 . 1998 . 9537516 . 10.1016/S0014-5793(98)00141-0 . 25328791 . free .
• Barritt DS, Pearn MT, Zisch AH, Lee SS, Javier RT, Pasquale EB, Stallcup WB . The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2 . J. Cell. Biochem. . 79 . 2 . 213–24 . 2000 . 10967549 . 3501957 . 10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G .
• Lee SS, Glaunsinger B, Mantovani F, Banks L, Javier RT . Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins . J. Virol. . 74 . 20 . 9680–93 . 2000 . 11000240 . 112400 . 10.1128/JVI.74.20.9680-9693.2000 .
• Mancini A, Koch A, Stefan M, Niemann H, Tamura T . The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity . FEBS Lett. . 482 . 1–2 . 54–8 . 2000 . 11018522 . 10.1016/S0014-5793(00)02036-6 . 40159587 .
• Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C . Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1 . J. Biol. Chem. . 276 . 16 . 12974–82 . 2001 . 11150294 . 10.1074/jbc.M008089200 . free .
• Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML . TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm . Genes Dev. . 15 . 10 . 1229–41 . 2001 . 11358867 . 313800 . 10.1101/gad.888601 .
• Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S . Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule . J. Biol. Chem. . 277 . 1 . 455–61 . 2002 . 11689568 . 10.1074/jbc.M109005200 . free . 2433/148697 . free .
• Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR . Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo . Biochem. J. . 361 . Pt 3 . 525–36 . 2002 . 11802782 . 1222335 . 10.1042/0264-6021:3610525 .
• Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E . Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells . J. Cell Biol. . 159 . 2 . 361–72 . 2002 . 12403818 . 2173042 . 10.1083/jcb.200207050 .
• Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P . CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors . Brain Res. Mol. Brain Res. . 117 . 1 . 47–57 . 2003 . 14499480 . 10.1016/S0169-328X(03)00283-3 .
• Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE . SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation . Neuron . 43 . 4 . 563–74 . 2004 . 15312654 . 10.1016/j.neuron.2004.08.003 . 17190912 . free .
• van de Pavert SA, Kantardzhieva A, Malysheva A, Meuleman J, Versteeg I, Levelt C, Klooster J, Geiger S, Seeliger MW, Rashbass P, Le Bivic A, Wijnholds J . Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure . J. Cell Sci. . 117 . Pt 18 . 4169–77 . 2005 . 15316081 . 10.1242/jcs.01301 . free .
• Coyne CB, Voelker T, Pichla SL, Bergelson JM . The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction . J. Biol. Chem. . 279 . 46 . 48079–84 . 2005 . 15364909 . 10.1074/jbc.M409061200 . free .
• Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW . Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux . J. Biol. Chem. . 280 . 47 . 39653–64 . 2006 . 16192269 . 10.1074/jbc.M510187200 . free .
• Heydecke D, Meyer D, Ackermann F, Wilhelm B, Gudermann T, Boekhoff I . The multi PDZ domain protein MUPP1 as a putative scaffolding protein for organizing signaling complexes in the acrosome of mammalian spermatozoa . J. Androl. . 27 . 3 . 390–404 . 2006 . 16452527 . 10.2164/jandrol.05166 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M . Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns . Genome Biology . 8 . 8 . R154 . 2007 . 17672918 . 2374985 . 10.1186/gb-2007-8-8-r154 . free .

Notes and References

1. Web site: Entrez Gene: MPDZ multiple PDZ domain protein.
2. Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C . Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1 . J. Biol. Chem. . 276 . 16 . 12974–82 . April 2001 . 11150294 . 10.1074/jbc.M008089200 . free .
3. Ullmer C, Schmuck K, Figge A, Lübbert H . Cloning and characterization of MUPP1, a novel PDZ domain protein . FEBS Lett. . 424 . 1–2 . 63–8 . March 1998 . 9537516 . 10.1016/s0014-5793(98)00141-0. 25328791 . free .
4. Mancini A, Koch A, Stefan M, Niemann H, Tamura T . The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity . FEBS Lett. . 482 . 1–2 . 54–8 . September 2000 . 11018522 . 10.1016/s0014-5793(00)02036-6. 40159587 .
5. Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR . Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo . Biochem. J. . 361 . Pt 3 . 525–36 . February 2002 . 11802782 . 1222335 . 10.1042/0264-6021:3610525.