MOTS-c explained

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a peptide encoded in mitochondrial DNA. It is believed to be involved in skeletal muscle and glucose metabolism. It is upregulated in response to exercise, and is considered an exercise mimetic.[1] [2]

MOTS-c binds to casein kinase 2.[3]

Society and culture

Researchers discovered MOTS-c in 2015.[4]

MOTS-c is not approved to treat any medical condition and is banned by the World Anti-Doping Agency, explicitly beginning in 2024.[5]

Notes and References

  1. Lee . Changhan . Kim . Kyung Hwa . Cohen . Pinchas . MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism . Free Radical Biology and Medicine . 1 November 2016 . 100 . 182–187 . 10.1016/j.freeradbiomed.2016.05.015 . 27216708 . 5116416 . 0891-5849.
  2. Dieli-Conwright . Christina M. . Sami . Nathalie . Norris . Mary K. . Wan . Junxiang . Kumagai . Hiroshi . Kim . Su-Jeong . Cohen . Pinchas . Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors . Scientific Reports . 19 August 2021 . 11 . 1 . 16916 . 10.1038/s41598-021-96419-z . 34413391 . 8376922 . 2021NatSR..1116916D . 2045-2322.
  3. Kumagai . Hiroshi . Kim . Su-Jeong . Miller . Brendan . Natsume . Toshiharu . Lee . Shin Hyung . Sato . Ayaka . Ramirez . Ricardo . Wan . Junxiang . Mehta . Hemal H . Yen . Kelvin . Cohen . Pinchas . Casein kinase 2 is a direct binding partner and a functional target of the exercise-mimetic microprotein MOTS-c . Physiology . May 2023 . 38 . S1 . 10.1152/physiol.2023.38.S1.5725846 . 258979715 . en . 1548-9213.
  4. Wan . Wei . Zhang . Lieliang . Lin . Yue . Rao . Xiuqing . Wang . Xifeng . Hua . Fuzhou . Ying . Jun . Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging . Journal of Translational Medicine . 2023 . 21 . 1 . 36 . 10.1186/s12967-023-03885-2 . 36670507 . 9854231 . en . free .
  5. Web site: Explanation of Key Changes on the 2024 WADA Prohibited List . 6 December 2023 . 13 October 2023.

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